|Place of Origin:||China|
|Minimum Order Quantity:||10g|
|Packaging Details:||Foil bag|
|Delivery Time:||3-5 work days|
|Payment Terms:||T/T, Western Union, MoneyGram, Bitcoins|
|Supply Ability:||Mass in stock|
|Product Name:||GW-0742||Alias:||GW0742;Acetic Acid; GW 0742X|
|Melting Point:||134.5-135.5 °C||Boiling Point:||591.476°C At 760 MmHg|
|Flash Point:||311.514°C||Storage Temp:||2-8°C|
China High Purity SARMS GW0742 CAS 317318-84-6 powder Help Bodybuilding Factory Supply
Product Name: GW0742
CAS No.: 317318-84-6
Other Names: GW0742
Grade Standard: food grade
Appearance: White Powder
Test Method: HPLC UV
Shelf life: 2 Years
What is GW-0742?
GW-0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.
GW-0742 is a synthetic high affinity PPAR β/δ agonist, and its possible role in preventing the advance of inflammatory and apoptotic processes induced by bleomycin, that long-term leads to the appearance of pulmonary fibrosis. Our data showed that GW0742-treatment (0.3 mg/Kg, 10 percent DMSO, i.p.) has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of: 1) cytokine production; 2) leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (MPO) activity; 3) IkBα degradation and NF-kB nuclear translocation; 4) ERK phosphorylation; 5) stress oxidative by NO formation due to iNOS expression; 6) nitrotyrosine and PAR localization; 7) the degree of apoptosis, evaluated by Bax and Bcl-2 balance, FAS ligand expression and TUNEL staining. Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO-instillation in mice.
Product: GW0742 Functions
1. GW0742 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation .
2. GW0742 has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human.
GW 0742 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW 0742 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation .
GW0742 has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human.
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Our Advantages :
Professional packing with professional materials, and We'll give clients several Packing way to choose after you contact me through my email.
Our company is a professional leading factory in China in pharmaceutical area, ach batch of steroid powders have to tested by our QC(quality control) department before they are allowed to sell.
We can pack your powders within 48 hours after your payment, and corresponding picture of your powders' parcel will be sent to you.
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