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Sertraline HCL is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs).
The way the drug works is not yet fully understood. Is thought to positively affect the communication between the nerve cells of the central nervous system and / or restore the chemical balance in the brain.
Sertraline for the treatment of depression, obsessive-compulsive disorder, panic disorder, anxiety, post-traumatic stress disorder (PTSD) and premenstrual anxiety (PMDD).
|Product Name||Sertraline hydrochloride|
|Product Categories||Pharmaceutical Intermediates;Active Pharmaceutical Ingredients;APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor;API;KETEK|
Sertraline is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline is primarily prescribed for major depressive disorder in adult outpatients as well as obsessive-compulsive disorder, panic disorder, and social anxiety disorder, in both adults and children.
Differences with other newer antidepressants are subtle and mostly confined to side effects. It has a similar tolerability profile to other SSRIs, with the types of adverse events usually including diarrhea, nausea, and sexual dysfunction. The incidence of diarrhea was higher with sertraline-especially when prescribed at higher doses-in comparison to other SSRIs.
Sertraline is used for a number of conditions including: major depression, obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social anxiety disorder.It has also been used for premature ejaculation and vascular headaches but evidence of the effectiveness in treating those conditions is not robust.
Marketed as (among and other brands) the first compound developed specially for the treatment of premature ejaculation (PE) in men 1864 years old. works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, was initially created as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.
Treat male premature ejaculation and erectile dysfunction. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug's accumulation in the body, and therefore reducing side effects.
|Description||A white or almost white crystalline powder||white crystalline powder|
|IR spectrum||Concordant with the working reference||Complies|
|Discrimination chloride||Forward reaction||Complies|
|HPLC||Concordant with the working reference||Complies|
|Sulphated ash||≤0.1 %||0.04%|
|Optical rotation||+36.0 ~ 42.0||+39.2|
|Solubility||Insoluble in dimethyl sulfoxide and sparingly soluble in methanol||Complies|
|Melting point||242 ~ 248ºC||243ºC ~ 245ºC|
|Loss on drying||≤ 0.5 %||0.13%|
|Assay [C18 ODS colum]||98.5 % ~101.5 %(on dried basis)||99.7%|
|Assay [with chiral colum]||≥97.0 %||97.8 %|
|Conclusion||Meets the Requirements|
Definition ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of sertraline and hydrogen chloride. A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as an antidepressant for the treatment of depression, obsessive-compulsive diso der, panic disorder and post-traumatic stress disorder.
According to the provisions of the doctor, taking sertraline. Follow all directions in your prescription label. Your doctor sometimes changes your dose to ensure you get the best results. Do not use the drug in a larger or smaller amount or longer than the recommended drug.
Sertraline can be with or without food. Take medications at the same time every day.
The liquid (oral concentrate) form of sertraline must be diluted first. To ensure that you are receiving the correct dose, use the provided drug dropper to measure the fluid. Mix 4 ounces (half a cup) of water, ginger, lemon / lime soda, lemonade or orange juice. Do not use any other liquid to dilute the drug. Stir the mixture and drink immediately. To ensure that you are able to get the entire dose, add a little water to the same glass, gently rotate and drink immediately.
This medicine may cause you to conduct a false positive drug screening test. If you provide urine samples for drug screening, please inform the laboratory staff that you are taking sertraline.
Symptoms can be improved before it may take 4 weeks. Follow the instructions to continue using the medication and tell the doctor whether your symptoms are improving.
Do not suddenly stop using sertraline, otherwise there may be unpleasant withdrawal symptoms. Ask your doctor how to safely stop using sertraline.
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