Uterine contractions Steroids Polypeptide Human Growth Hormone Peptide Oxytocin CAS 50-56-6

Uterine contractions Steroids Polypeptide Hormones Oxytocin CAS 50-56-6

Quick Detail:

Description:

Oxytocin (Oxt) is a mammalian neurohypophysial hormone. Produced by the hypothalamus and stored and secreted by the posterior pituitary gland, oxytocin acts primarily as a neuromodulator in the brain.
Oxytocin plays an important role in the neuroanatomy of intimacy, specifically in sexual reproduction of both sexes, in particular during and after childbirth; its name, meaning "swift childbirth", comes from Greek, oksys "swift" and , tokos "birth." It is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, maternal bonding, and, after stimulation of the nipples, lactation. Both childbirth and milk ejection result from positive feedback mechanisms.

Oxytocin has been best known for its roles in female reproduction. It is released in large amounts during labor, and after stimulation of the nipples. It is a facilitator for childbirth and breastfeeding. However, recent studies have begun to investigate oxytocin's role in various behaviors, including orgasm, social recognition, bonding, and maternal behaviors.

This small nine amino acid peptide is now believed to be involved in a wide variety of physiological and pathological functions such as sexual activity, penile erection, ejaculation, pregnancy, uterine contraction, milk ejection, maternal behavior, social bonding, stress and probably many more, which makes oxytocin and its receptor potential candidates as targets for drug therapy.

Application:

Injected oxytocin analogues are used for labor induction and to support labor in case of difficult parturition. It has largely replaced ergometrine as the principal agent to increase uterine tone in acute postpartum hemorrhage. Oxytocin is also used in veterinary medicine to facilitate birth and to stimulate milk release.

The tocolyticagent atosiban (Tractocile) acts as an antagonist of oxytocin receptors; this drug is registered in many countries to suppress premature labor between 24 and 33 weeks of gestation. It has fewer side effects than drugs previously used for this purpose (ritodrine, salbutamol, and terbutaline).

Oxytocin is a neuropeptide produced in the hypothalamus and secreted by the pituitary gland.

Oxytocin is released during sex, childbirth and lactation to aid reproductive functions.

This neuropeptide exerts multiple psychological effects, influencing social behavior and emotion.

Oxytocin is prescribed for a variety of obstetric and gynecological reasons, including to aid in childbirth.

High levels of the "love hormone" have been observed in couples in the first six months of a relationship.

Oxytocin has an anti-anxiety (anxiolytic) effect and may increase romantic attachment and empathy.

Research shows that oxytocin may have beneficial effects for people with autistic spectrum disorders.

Oxytocin appears to play a role in protecting the intestine from damage, with potential for use in treatment of irritable bowel disease.

Usage and dosage:

Odinopoeia or oxytocin intravenous drip, once the 2.5 - 5 units, with Sodium Chloride Injection diluted to each 1ml contains 0.01 units. Intravenous drip of the beginning of every minute of not more than 0.001 to 0.002 units, each 15 - 30 minutes increased 0.001 to 0.002 units, to achieve the contractions and normal childbirth is similar, the fastest per minute of not more than 0.02 units, usually 0.002 to 0.005 units per minute.

Control postpartum hemorrhage per minute intravenous drip of 0.02 - 0.04 units, expulsion of the placenta after intramuscular injection of 5 to 10 units.
Lactogenic just before a 2 - 3 minutes, with nasal drops a 3 drop, drop into one side or both sides of the nostril.

Preparation and specification : oxytocin injection (1) 0.5ml:2.5 units (2) 1ml:5 (3) 1ml units 10 units;
Oxytocin nasal drops 1ml:40 units. The induction of labor or prenatal uterine atony: in 2.5-5 units in 500ml 5% glucose for intravenous drip slowly (10-30 drops / minute), maximum time 20 units. (2). Prevention of postpartum hemorrhage: intramuscular injection of 5-10 on each unit, or 5% glucose solution for intravenous drip.

The main contraindication, heart disease, a caesarean history and more than three fetal maternal disable.

Do NOT use oxytocin if:

1. you are allergic to any ingredient in oxytocin

2. your birth canal is too small compared with the fetus's head

3. the fetus is in a difficult position within the womb or is in distress and delivery is not progressing

4. you have other complications that require medical intervention for birth

5. you have bacteria in the blood

6. you cannot have a child through vaginal delivery because of certain conditions (eg, genital herpes, cervical cancer)

Contact your doctor or health care provider right away if any of these apply to you.

Oxytocin COA

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