Anti Estrogen Steroids Formestane / Lentaron Cancer Treatment CAS 566-48-3

Anti-Estrogen Steroids Formestane /Lentaron Cancer Treatment CAS 566-48-3

Quick details

Formestane/Lentaron Powder description:

Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones.

It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor. It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes.

Formestane has poor oral bioavailability, and thus must be administered forthnightly (bi-weekly) by intramuscular injection. Some clinical data has suggested that the clinically recommended dose of 250mg was too low.

With the discovery of newer, non-steroidal and steroidal, aromatase inhibitors which were orally active and less expensive than formestane, formestane lost popularity.

Currently, formestane (categorized as an anti-estrogenic agent) is prohibited from use in sports in accordance to the regulations of the World Anti-Doping Agency. It is not US FDA approved, and the intramuscular injection form of formestane (Lentaron) which was approved in Europe has been withdrawn.
 

Formestane/Lentaron Powder Indications/Purpose:

Aromatase converts androstenedione to estrone, and also converts testosterone to estradiol. Lentaron is often used to suppressestrogen production during anabolic steroids and prohormone cycles.

Due largely to Lentarons similarity to androstenedione, it also acts as a prohormone to 4-hydroxytestosterone , an active steroid which displays weak androgenic activity in addition to serving as a mild aromatase inhibitor.

Male bodybuilders and athletes also use it to prevent estrogenic side effects from anabolic steroids, to improve fat loss, and to increase muscle definition while dieting.

However, several conclusive studies have demonstrated Lentarons estrogen blocking inferiority when compared to third generation AIs like Arimidex (anastrozole) and Femara (Letrozole) so its far less popular.
 

Formestane/Lentaron Powder Mechanism of action:

Formestane is a second generation, irreversible, steroidal aromatase inhibitor. It inhibits the aromatase enzyme responsible for converting androgens to estrogens, thereby preventing estrogen production.

Breast cancer may be estrogen sensitive or insensitive. A majority of breast cancers are estrogen sensitive. Estrogen sensitive breast cancer cells depend on estrogen for viability.

Thus removal of estrogen from the body can be an effective treatment for hormone sensitive breast cancers. Formestane has been targeted specifically for the treatment of postmenopausal women.

Unlike premenopausal women who produce most estrogen in the ovaries, postmenopausal women produce most estrogen in peripheral tissues with the help of the aromatase enzyme.

Formestane, an aromatase inhibitor, can thus help to decrease the local production of estrogen by blocking the aromatase enzyme in peripheral tissues (ie. adispose tissue of the breast) to treat hormone sensitive breast cancer.
 

Formestane/Lentaron Powder Side Effects:

The side effects which accompany Lentaron use are also those that are common to other AI drugs including fatigue, mood swings, depression, joint pain, hot flashes, headaches, swelling of the arms and legs, and high blood pressure. AIs also suppress HDL (good) cholesterol levels, and may decrease bone density increasing susceptibility to osteoporosis, fractures and breaks.
 

COA:

HPLC

Tips:

HOW TO MAKE AN ORDER?

1. Tell us what you need ( use for what/product name & quantity ), you will get an advice and a quotation.

2. Full payment would be done once we come to an agreement on all details .

3. Your goods will be sent out within 24 hours after payment , tracking number available.

4. The goods will reach you in 3~7 days.

WHY CHOOSE US?

1. High quality: Our factories are professional in raw powder production with experience over 10 years. Having good reputation all over the world, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.

2. Competetive price: All powders are factory directly supplied, it's factory price and negotiable.

3. Fast and safe delivery: Your goods will be sent out within 24 hours after payment, tracking number available, customs pass rate ≥99%.

4. Good pre&after-sales service: Any problem please feel free to contact us, we will always be online for you.

High quality, competetive price, fast and safe delivery, good service,that's us! Welcome to contact!

Some other products: