Place of Origin: | China |
Brand Name: | Pharmlab |
Certification: | ISO 9001, USP,GMP |
Model Number: | 119356-77-3 |
Minimum Order Quantity: | negotiation |
---|---|
Price: | negotiation |
Packaging Details: | Disguised package ;Foil bag |
Delivery Time: | 3-5 work days |
Payment Terms: | EMS,HKEMS,FEDEX,DHL,TNT,Aramex,ETC |
Supply Ability: | Mass in stock |
Product Name: | Hydrochloride | CAS: | 119356-77-3 |
---|---|---|---|
Appearance: | White To Off-White Cyrstalline Solid | Grade: | Pharmaceutical Grade |
Shipping Methods: | EMS,HKEMS,FEDEX,DHL,TNT,Aramex,ETC | Trademark: | Parmlab |
High Light: | natural male enhancement supplements,male enhancement pills |
Product name |
Hydrochloride |
Other name |
DL- |
CAS register number |
119356-77-3 |
Molecular formula |
C21H23NO.ClH |
Molecular weight |
341.88 |
Molecular structure |
|
Assay |
98% |
Appearance |
White to Off-White Cyrstalline Solid |
Package |
25kg/drum or as required |
Usage |
can be used as pharmaceutical material |
Minimum order quantity |
25KG |
Shipping |
By express courier |
Shipping leading time |
Within 12 hours after receiving the payment |
Payment options |
Western Union, MoneyGram, T/T,Banktransfer |
Price |
Negotiated |
Hydrochloride is a drug that is used to treat premature ejaculation in men. It is available by prescription and is taken orally, prior to sexual intercourse. The drug belongs to the class called serotonin reuptake inhibitors (SSRIs), which have mainly been used to treat depression.
Sexual dysfunction, including premature ejaculation, is an extremely common condition worldwide. The cause of premature ejaculation has not been fully elucidated, but may include both psychological and physiological factors. Premature ejaculation refers to a short ejaculation time, which can affect the satisfaction of both partners during sexual intercourse.
To treat premature ejaculation, both psychological and physiological factors need to be managed. From a pharmacological point-of-view, to treat the physiological aspect of premature ejaculation, hydrochloride is one of the first oral drugs to be made available. Psychological treatment may be given concomitantly, as the condition is multifactorial.
One of the possible adverse effects reported with SSRIs when used to treat depression is delayed ejaculation. This reported adverse effect led to the studies of hydrochloride, using the effect therapeutically. It is thought that serotonin may be involved in the inhibition of ejaculation. By blocking the serotonin reuptake in men suffering from premature ejaculation, the time to ejaculation may be prolonged.
Hydrochloride is a white powder substance and water-soluble. Taken 1-3 hours before sexual activity, it is rapidly absorbed in the body. Its maximum plasma concentration (Cm) is reached 1-2 hours after oral administration.
Randomized, double blind, placebo-controlled trials have confirmed the efficacy of for the treatment of PE.Different dosage has different impacts on different type of PE. 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. , given 1-3hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE.
Since PE is associated with personal distress, interrelationship difficulty, provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE.
Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used.However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction.
On the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.
Analysis |
Specifications |
Results |
Appearance |
White or almost white crystalline powder |
Complies |
Identification |
IR |
Complies |
Loss on drying |
≤2.0% |
0.5% |
Melting Point |
175°Cto 185°C |
180°C |
Specific rotation |
+128°±3° |
183°C+127°C |
Chromatographic impurities |
||
A. Single impurity |
≤0.2% |
Complies |
B. Total impurities |
≤0.5% |
0.3% |
Assay |
98.0% to 102.0% |
99.2% |
Conclusion: Conform to the Enterprise standard |
Initial dose: 50 mg orally once a day, as needed, 1 hour prior to sexual activity
Maintenance: 25 to 100 mg orally once a day, as needed, 1 hour prior to sexual activity
Comments: This drug may be taken anywhere from 30 minutes to 4 hours before sexual activity.
1. Quality : we deal with steroid relevant products over 15 years, and have many stable customers from all over the world. All of them witness our products' quality.
2. Package : Different package for different customs results in high rate of customs clearance.
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