|Place of Origin:||China|
|Certification:||ISO 9001, USP,GMP|
|Minimum Order Quantity:||negotiation|
|Packaging Details:||Disguised package ; Foil bag|
|Delivery Time:||3-5 work days|
|Payment Terms:||Western Union, MoneyGram, T/T, Bitcoin|
|Supply Ability:||Mass in stock|
|Appearance:||White Crystal Or Crystalline Powder||Shipping Methods:||EMS,HKEMS,FEDEX,DHL,TNT,Aramex|
|Shipping Policy:||100% Free Resend Policy||Email:||RAWSGEAR|
topical anesthetic drugs,
pain killer powder
|Product Category||Pharmaceutical raw materials and intermediates|
|Product content||98.0% -102.0%|
|Packing Specification||25KG / plastic woven bag or 25KG / fiber drum|
|Appearance||white crystal or crystalline powder|
|Usage||Antipyretic analgesic bulk drugs|
1.Paracetamol is well absorbed in the gastrointestinal tract. Oral bioavailability is dose dependant: with larger doses, the hepatic first pass effect is reduced due to overwhelming of the liver enzymatic capacity; and therefore, bioavailability is increased.
2.Rectal administration of paracetamol is also feasible. In this case, bioavailability is inconsistent and in overall reduced, due to incomplete dissolution of the suppository in the rectum. The absorption rate through this route of administration is elongated.
3.Paracetamol is distributed throughout the body fluids in a homogeneous way. The analgesic activity is attributable to the small fraction that penetrates into the brain. Paracetamol given at therapeutic doses binds to plasma proteins at less than 20%. In case of intoxication, this proportion may increase to up to 50%.
4.Paracetamol is essentially metabolized in the liver by conjugation with glucuronic acid (55%) and sulfuric acid (35%). Hepatotoxic metabolites are produced in small amounts by the cytochrome P450 (isoenzyme CYP2E1). In the therapeutic plasma concentration range, this metabolite is detoxified by conjugation with glutathione. In case of intoxication the amount of this toxic metabolite increases and outweighs the amount of available glutathion, which can lead to hepatic failure and renal tubular necrosis.
|Appearance||White or almost white ,crystalline powder.||White,crystalline powder.|
|Water||Not more than0.5%||0.08%|
|Related substance||Impurity(chloroacetanilide)not more than 10 ppm||2ppm|
|Impurity K(4-aminophenol)not more than 50 ppm||15 ppm|
|Impurity F(4-nitrophenol)not more than 0.05%||Not detected|
|any other impurity not more than 0.05%||0.01%|
|Total of other impurities not more than 0.1%||0.02%|
|Residue on ignition||Not more than 0.1%||0.05%|
|Chloride||Not more than 0.014%||Less than 0.014%|
|Sulfate||Not more than 0.02%||Less than 0.02%|
|Heavy metals||Not more than 0.001%||Less than 0.001%|
|Free p-aminophenol||Not more than 0.005%||Less than 0.005%|
|Limit of P-chloroacetanilide||Not more than 0.001%||Less than 0.001%|
|Readily carbonizable substances||Conforms||Conforms|
|Residual solvents||Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5%||0.08%|
|Conclusion: Complies with USP34 / BP2011|
A: Adults including elderly and children over 12 years: 1 or 2 tablets every 4 to 6 hours as required, to a maximum of 8 tablets in a day.
B: Children 6-12 years: Half to 1 tablet every 4-6 hours as required, to a maximum of 4 tablets in a day.
C: Children under 6 years: Not recommended.
A: Keep out of the reach and sight of children.
B: Store below 25° C in a dry place, protected from light.
C: Do not use Paracetamol tablets after the expiry date stated on the label/carton/bottle. The expiry date refers to the last day of that month.
1. High quality with competitive price
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2. Fast and safe delivery
1). Parcel can be sent out in 24 hours after payment.Tracking number available
2). Secure and discreet shipment.Various transportation methods for your choice.
3). Customs pass rate ≥99%
4). We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
3. We have clients throughout the world
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.
Contact Person: Moran