129453-61-8 Pharmaceutical Raw Materials Anti Estrogen Steroids Fulvestrant Faslodex For Cutting Cycle

Anti-Estrogen Steroids Fulvestrant Faslodex For Cutting Cycle 129453-61-8

Quick Details:

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• Fulvestrant
• CAS: 129453-61-8
• MF: C32H47F5O3S
• MW: 606.77
• Usage: Antiestrogen; A novel steroidal estrogen antagonist reported to lack any partial agonist activity. Antineoplastic (hormonal).
• Purity: 99.56%
• Appearance: White crystalline powder
• Min. Order: 1g
• Package: Super discreet to ensure 100% pass rate
• Stock: Mass and plenty---Prompt shipment
• Payment: T/T, Bank Transfer, Western Union, Money Gram and Bitcoin
• Delivery: All Express Modes (EMS, DHL, TNT, FedEx, UPS, etc.)
• Shipping time: 5-7 days by express door-to-door

Description:

Fulvestrant, sold under the trade name Faslodex among others, is used to treat hormone receptor positive breast cancer (breast cancer that depends on hormones such as estrogen to grow) in women who have experienced menopause (change of life; end of monthly menstrual periods) and whose breast cancer has worsened after they were treated with antiestrogen medications such as tamoxifen (Nolvadex). It works to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression as well as HR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrine therapy.

It is given by injection into a muscle.

Medicine for breast cancer

Fulvestrant (trade name Faslodex) which was developed by AstraZeneca isan intramuscular injection drug, and it was approved for marketing by the US Food and Drug Administration in April 2002.Fulvestrantis a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells.Many breast cancer cells have estrogen receptor (ER), and these cancers rely on the hormone oestrogen to grow, This type of breast cancer is called oestrogen-receptor positive (ER positive) breast cancer. Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells.

Fulvestrant stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cells have.Thus, fulvestrant is a " pure" estrogen receptor antagonists, it has no partial estrogen-like effect of excitement, which can inhibit estrogen signaling pathway by binding, blocking and reduced ER. Fulvestrant has competitively combine with ER, its binding capacity with ER was the same as estrogen, but is about 100 times as tamoxifen.Fulvestrant provided effective second-line therapy in this setting for postmenopausal women whose breast cancer has worsened after they were treated with antiestrogen medications such as tamoxifen.Fulvestrant is a hormone therapyand itdoes not cause common adverse reactions as in chemotherapy, so it has a better patient compliance. A number of clinical studies have approved that a dosage of 250mgfulvestrant has a outstanding effect and security stability in the second-line treatment of advanced breast cancer.

Mechanism of action

Fulvestrant is a steroid anti-estrogen drugs, its chemical structure is almost like estradiol, the difference is that there is functional group at 7α position, thus it is a analogues of 17β-estradiol alkylamines. Many breast cancer cells have estrogen receptor (ER) which are stimulated to grow by the female sex hormones oestrogen and progesterone. Fulvestrant can stop oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cells have.It can antagonize the action of estrogen by occupying the ER, and thereby suppress stimulation of gene activation by estrogen, so as toaffect estrogen related processes required by cell cycle.Its affinity with ER is close to estrogen, which is100 times as tamoxifen. Apoptosis is very essential in maintaining homeostasis, and it could also be another major mechanism offulvestrant therapy.

Fulvestranthas poor oral bioavailability, it comes as a solution (liquid) in the buttockto be administeredvia intramuscular injection once a month.Open, randomized and multi-center study in postmenopausal women with advanced breast cancer showed that dosage ofonce 5 ml or twice 2.5 ml injection of fulvestrant product 250 mg have no significant difference on pharmacokinetic and toxicity,but have individual differences in blood concentration and dose-dependent manner. The serum LH, FSH or SBHG levels did not change significantly during 7d treatment. Fulvestrant can`t pass into blood-brain barrier to cause side effects such as vasomotor.Theoretically, estrogen inactivation can lead to increased bone turnover, promote osteoporosis, however this dosen`t happenedin animal models. Fulvestrant can`t lead to increased surrogate marker of bone turnover.

Uses

Fulvestrant is used to treat hormone receptor positive breast cancer (breast cancer that depends on hormones such as estrogen to grow) in women who have experienced menopause (change of life; end of monthly menstrual periods) and whose breast cancer has worsened after they were treated with antiestrogen medications such as tamoxifen (Nolvadex). Fulvestrant is in a class of medications called estrogen receptor antagonists.

Package

We do understand that you will be worried about our packing methods before you tried or knew us, while we are making the real deal and we do know how customs works.

We have professional team for special disguised package, no word concern steroid will be whown on the parcels, the pass custom rate is more than 99%.

Before we could be able to offer some details of our package and shipping methods, and it is better to discuss by mail , skype or whatsapp.

Delivery

Our company owns a professional and efficient team for packing with our best discrete or stealth packages. Orders will be sent out within only one working day after payment.Package details and tracking number will be sent to you.Shipment by DHL, TNT, FedEx, HKEMS, UPS, ,EUB,ETK and so on.

It usually takes 4 to 7 days or 7 to 10 days by some other express courier; it will be 15 to 20 days by slow post.

Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.

We will stack on the parcels until you get them on hand so that you do not need to spare time on this.

Our commitment:

1. Quality assurance

With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

2. Safe transportation

Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 3-5 to your product.

3. The product diversity

Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter. We absolutely guarantee that you can very safely use our products

4. High quality service 

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.