HGH Peptide Sterile Filtered White Lyophilized Powder 1mg/Vial Fst 344 Follistatin 344

1mg/Vial White Lyophilized Powder Ace 031 Peptides For Bodybuilding

1. Specifications: 1MG/vial
2. Package: 10vials=1kit
3. Purity > 99%
4. Storage temperature: 2-8 Celsius degree
5. Quality guarantee period: 2 years in 2-8 Celsius degree
6. Vial color: transparent color / Top color: blue/green/red/yellow/ customized
7. Physical Appearance: freeze-dried powder in white
8. Place of origin: China
9. Certification: HPLC, MSDS

Introduction

ACE-031 is a soluble fusion protein that has been shown to increase muscle mass and strength in research studies. ACE-031 is being studied as a treatment for metabolic diseases, renal neoplasms of childhood, cardiovascular anomalies, age-related muscle loss, and cancer treatment related muscle loss and neuromuscular diseases. ACE-031 is a biologic therapeutic, based on activin receptor type IIB (ActRIIB). The molecule inhibits signaling via the ActRIIB receptor binding and increase muscle mass and strength. ACE-031 is a recombinant fusion protein that is artificially synthesized by fusion of standard antibody and a portion of ActRIIB receptor. The recombinant fusion protein eliminates myostatin and other biomolecules that limit muscle strength or growth.

ACE-031 Stability:

Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.

How ACE-031 works?

1) ACE-031 is a fusion protein that is soluble and is known to have a positive feedback mechanism in the increasing muscle strength and mass. The polypeptide is under research for the treatment of various condition and diseases such as metabolic diseases, cardiovascular anomalies, renal neoplasms during childhood, cancer, age related muscle loss and other neuromuscular diseases. ACE-031 is biopeptide that has therapeutic properties that are mainly based on the activin receptor type 2 or ActRIIB. The polypeptide inhibits cell signaling by blocking ActRIIB receptor thereby increasing muscle strength and mass. It is an artificially synthesized polypeptide of the natural antibody and a part of the ActRIIB receptor. When recombinant technology is used to fuse the proteins, it eliminates myostatin and other biomolecules that limit muscle growth and strength. ACE-031 is classified under the category of proteins in the TGF-beta super family, which are essential in the regulation of muscle growth and strength.

2) ACE-031 mechanism of action is through the switching on and up regulation of the muscle growth process, experimental studies reveal that the polypeptide acts by inhibiting the ActRIIB receptor and promotes myoblasts differentiation, development, and maturity. According to studies administration of ACE-031 for 2 weeks increases skeletal muscle density, increases adiponectin levels and reduces leptin level in the system. The polypeptide is composed of 368 amino acids in the sequence; this makes a very large and complex polypeptide. Muscle growth is mainly accentuated by the production of muscle cells and this occurs via the amino acids and other essential components. TGF beta protein super family, which is the main regulator in the switching on and off the muscle development through the amino acids. When the ActRIIB receptors interact with GDF-8, it causes a signal transduction which in causes the initiation of myoblasts differentiation, development and maturity.

3) ACE-031 is a protein under research for enhancing muscle cell differentiation in a recombinant fusion is vital in inhibiting factors that limit muscle growth and generation of myoblasts by endogenous binding to the cells. The blockage of the antagonist causes an enhanced production of myoblasts, muscle function and improved muscle strength. The mechanism can prove to be essential in dealing with problems such as muscular dystrophy, androgen deprivation, and muscle loss associated with corticosteroids among other conditions. Unlike the generation of mutation specific ribonucleotide based therapy, the clinical development for Duchene muscular dystrophy or what is commonly called DMD, ACE-031 can be very beneficial because it is not affected by existing mutations.

Effects

Women weight loss

For overweight women were given a dose of 250 mg (mg) Ace 031. As a result, after one month, thigh muscle grew more than a pound. In addition, their lean weight increased by 3%, which is quite a result.

Fat loss and bone health

In the different studies conducted, the subjects experienced a decrease in leptin concentration and promoted adiponectin, which was a "good fat" hormone. So maybe Ace-031 does help to lose weight. Another study shows that the increase in alkaline phosphatase in blood and the reduction of collagen peptides; this may mean that it also helps to strengthen the bones.

FSH

In the study with women, the concentration of FSH (follicle-stimulating hormone) decreased significantly and did not explain why. So there seems to be some side effects, we do not know whether men will happen the same thing. But we know that in the cattle, due to infertility, farmers refused to use Ace-031 "to strengthen" their stock.


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