Bodybuilding Selective Androgen Receptor Modulators LGD-4033 CAS 1165910-22-4

Quick Details

What is LGD-4033

Anablicum (LGD-4033) is a selective androgen receptor modulator (SARM), discovered by Ligand Pharmaceuticals Inc and perfected by SARMS1. LGD-4033 binds to the androgen receptor of muscle and bone selectively, exhibiting similar effects as testosterone, with only partial agonist activity on the prostate. It was developed as a way to treat diseases or conditions associated with muscle and bone deterioration. The advantage a SARM like LGD has over testosterone is the difference in activity it has on the body outside of muscle and bone.

Anabolicum (LGD-4033) is unarguably the strongest SARM on the market today as far as anabolic power. It adds extra muscle building power to a cutting cycle, strength and size to a bulking cycle, and resilience for the endurance athlete. Used by itself or stacked with one or more other compounds, LGD demands recognition in the world of health, fitness, and bodybuilding.

Ligandrol is an orally active nonsteroidal SARM developed by Ligand Pharmaceuticals that has completed Phase I clinical trials which involved multiple ascending doses in healthy volunteers.

According to the National Institute of Health's U.S. National Library of Medicine, in Phase I clinical trials "Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects." These clinical trials showed that humans could safely tolerate up to 22mg/day of this compound for 14 consecutive days; this compound contributed to increases in lean body mass, decreases in fat mass, increases in strength, as well as an increases in senses of well-being.

Ligandrol also appears to decrease bone turnover rate, which appeals to those with osteoporosis. Based on these findings, it appears that LGD4033 is an excellent SARM for bulking, cutting, recomposition, or strength-gain phases.

Ligandrol doesn't appear to decrease LH or FSH nor does it appear to increase PSA or estradiol, but it may decrease total testosterone, free testosterone, and SHBG, so a full PCT is recommended. More specifically, at dosages below 5mg/day, total testosterone may slightly decrease yet stay in the "healthy" reference range of 270~1070ng/dl while dosages above 5mg/day may decrease HDL and total testosterone values to clinical deficient values.

Tiger Fitness offers three products designed for PCT - Finaflex Revolution PCT, Lecheek AD3 PCT, and Athletic Xtreme Advanced PCT. If a PCT is performed correctly, it should jumpstart your body's natural production of testosterone and bring those values back in to the normal range.

How it works

LGD-4033 is a selective androgen receptor modulator a novel non-steroidal, oral SARM that binds to AR with high affinity (Ki of ~1 nM) and selectivity, class of androgen receptor (AR) ligands that is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss. LGD-4033 is expected to produce the therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action and an oral route of administration.

LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds to the androgen receptor with high affinity and selectivity. It demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands. LGD-4033 has recently completed a Phase I Multiple Ascending Dose study in healthy volunteers. This randomized, double-blind, placebo-controlled Phase I study established the safety and tolerability up to doses of 22 mg per day.

Clinical runs also showed that LGD-4033 has the ability to set off the following benefits when taken consistently:

• An increase in strength levels
• Lean muscle mass improved
• A drop in body fat
• Has healing properties
• Does not cause the undesirable side effects caused by prohormones and anabolic steroids

LGD-4033 Benefits

Anabolicum (LGD), like other popular SARMS, is very versatile and has a list of benefits no matter the goal of the user. Whether it's lean muscle mass, maintenance of your hard earned gains during a cutting cycle, or bridging the gap between steroid cycles, LGD-4033 can be a very beneficial tool.

Studies suggest that this SARM will lend therapeutic benefit to many testosterone deficiency conditions. In fact, it's not unheard of to hear of improvements in joint pain or nagging injuries after starting a course of Anabolicum (LGD), much like its cousin Ostarine (MK-2866). In addition, LGD can increase strength, vascularity, and fat loss while bulking, and it can help during "recomposition" (recomp).

Doses and Half-life

Anabolicum (LGD) is most commonly recommended at 5-10mg per day with once daily dosing schedule. The half-life of LGD is between 24-36hrs. It has been found to be well tolerated at up to 22mg/day in people.

The chart below outlines dosing recommendations based on your goal; all dosages can be taken one
per day and don't require an intra-week cycling protocol like Andarine:

Does LGD-4033 Have Any Side Effects

It is non-toxic and the side effects are very minimal. Thus, using LGD-4033 is recommended if you want to bulk up and drop fat sans steroids as we all know steroids have harsh side effects.

It won't affect your liver but a full PCT is advised after running LGD-4033. The suppression is higher than other SARMS (but lower than anabolics), thus the need for PCT.

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