Safe Pain Killer Drugs Mepivacaine Hydrochloride For Anti - Inflammatory / Analgesic

Local Anesthetic Drugs Mepivacaine Hydrochloride For Anti-inflammatory And Analgesic

Basic Info.

Pharmacological effects

Methapine hydrochloride is an aminoid local anesthetic. It acts on the sensory and motor nerve fibers, quick, long duration of efficacy, can effectively impede nerve conduction. Adrenaline in the anesthetic can slow the running speed of mepivacaine hydrochloride in the human body to ensure the time and effect of anesthesia, and to a certain extent, reduce the amount. Toxicological studies: Mayo cacaine hydrochloride on the human body lethal dose of 5 ~ 10μg / ml, compared with lidocaine and procaine toxicity is small. There are no animal experimental studies to determine its carcinogenicity, mutagenicity and reproductive toxicity. And no relevant information that this product may have carcinogenic, mutagenic and reproductive toxicity.

Pharmacokinetics

When used as a peripheral nerve conduction block, mepivacaine hydrochloride injection in the 2 to 4 minutes after the start effect. Its distribution in the body is 0.8, and the binding rate of plasma protein is 60 ~ 78% (mainly with oxygen - glycoprotein), its own pKa value of 7.6. Usually 600 mg of mepivacaine hydrochloride in the plasma half-time for 2 to 3 hours, and for liver disease and diabetes patients, the half-life will be extended. The metabolism of mepivacaine hydrochloride in the body is mainly done by the liver. The vast majority of them are decomposed by bile, and then absorbed through the urine through the urine (urine PH value may be affected). For cases of radioactive labeling of mepivacaine hydrochloride, 10% of the radioactive elements will be discharged from the lungs in the form of CO2. For adults, the undecomposed mepivacaine hydrochloride in the final excrement accounts for only 2.8 to 3.2% of its total, and this percentage is 43.3% for newborns.

Indications

Local anesthesia for oral and dental treatment (nerve block).

Usage and dosage

Usage: regional injection, not intravenous injection.

Dosage: 1 to 3 doses per adult treatment limit. Depending on the scope of anesthesia and the use of anesthesia technology. Injection speed: should not exceed 1ml per minute.

Adverse reactions

Ipricaine hydrochloride central nervous system: may be inhibited by amiprocaine hydrochloride or excitement, resulting in involuntary movement of the eye, lying language, headache, nausea and other symptoms. Respiratory system: breathing difficulties, and even apnea. Cardiovascular system: bradycardia, hypotension and so on. May lead to ventricular contraction, ventricular fibrillation, and even heartbeat stop. Allergic reactions: urticaria, edema and so on. The likelihood of these symptoms is small. Adrenaline cardiovascular disease and hypertensive patients are more sensitive to adrenaline, may be ischemic or tissue necrosis occurs. * Sulfite bronchial asthma patients allergic to sulfite, may cause some allergic symptoms, such as edema, urticaria and so on.

Contraindications

Amino-type anesthetics or similar drugs have allergic reactions.

* Heart disease caused by cardiovascular disease such as hypertension, arrhythmia, coronary artery or rheumatic heart disease.

* Taking compound tricyclic antidepressants and patients treated with monoamine oxidase.

【Precautions】

For the same patient, a course of treatment can only be used once, and the injection of Kaifeng once must be used immediately.

* Liver and kidney dysfunction as much as possible to avoid the use of the anesthetic.

* Avoid anesthesia on areas that have been infected or have redness.

* The injection should be slow and must be withdrawn to ensure that the needle is not in the blood vessel.

* This product contains vasoconstrictor and therefore can not be reused in the same area, so as not to cause necrosis

【Storage】 25 ℃ below the dark preservation, pay attention to moisture.

【Validity】Two years.

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Quality

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Our commitment

1. Quality assurance

With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

2. Safe transportation

Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 3-5 to your product.

3. The product diversity

Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter. We absolutely guarantee that you can very safely use our products

4. High quality service 

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

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