High Pure Local Anesthetic Drugs Ropivacaine Hydrochloride For Postoperative Pain

Local Anesthetic Drugs Ropivacaine Hydrochloride For Postoperative Pain

Basic Info.

Description

Ropivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain. Ropivacaine is used as a local (in only one area) anesthesia for a spinal block, also called an epidural. The medication is used to provide anesthesia during a surgery or C-section, or to ease labor pains.Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer. Ropivacaine may also be used for purposes not listed in this medication guide. Ropivacaine is indicated for local anaesthesia including infiltration, nerve block, epidural and intrathecal anaesthesia in adults and children over 12 years. It is also indicated for peripheral nerve block and caudal epidural in children 1-12 years for surgical pain. It is also sometimes used for infiltration anaesthesia for surgical pain in children.

Ropivacaine is often coadministered for epidural analgesia, for example in pregnant women during labour.

Application

(1) Surgical anesthesia: Epidural anesthesia (including epidural anesthesia during cesarean section); Local infiltration anesthesia.

(2) Acute pain control: For postoperative or labor analgesia continuous epidural infusion can be used can also be intermittent medication; Local infiltration anesthesia.

Pharmacological effects

Since the discovery of long-acting local anesthetic can induce cardiac arrest, people have been looking for less fat-soluble, more safe alternative drugs. Ropivacaine is such a new long-acting amide local anesthetic, its role for a long time, and has anesthesia and analgesic effect. Its pharmacological characteristics for the heart toxicity is low, sensory block and movement block separation is obvious, with peripheral vasoconstriction. So the drug is particularly suitable for postoperative analgesia and obstetric anesthesia.

Ropivacaine has the following advantages compared with traditional local anesthetic:

1, the effect of the role of ropivacaine significantly longer than other long-acting local anesthetic, subcutaneous infiltration of anesthesia more than the same concentration of bupivacaine 2 to 3 times longer.

2, the efficacy of unique - ropivacaine feeling - movement block separation is much greater than bupivacaine, and a higher clearance rate, making it more suitable for analgesic.

3, controllability - ropivacaine anesthetic effect in a dose-dependent, that is, ropivacaine produced by the degree of sensory and motor block can be predictable and controllable.

4, low side effects - ropivacaine is not the general long-term local anesthetic heart toxicity of the larger shortcomings, the goods rarely occur cardiotoxicity, and the fetus on the goods with good tolerance.

[Taboo]

Ropivacaine is insoluble over pH 6.0, resulting in precipitation in alkaline environments.

[Pecial note when saving]

Store at room temperature to avoid freezing.

[Nstructions]

Drugs without preservatives can only be used once, any liquid remaining in the open container must be discarded, the complete container can not be autoclaved, when the requirements of sterile appearance, you should choose the specifications of blister eye packaging.

[Precautions]

The implementation of regional anesthesia must be carried out on the basis of improved staff and equipment. Drugs and equipment for monitoring and emergency recovery should be readily available. In the implementation of a large anesthesia should be given to the patient before the establishment of intravenous access. The relevant clinical staff should be properly trained and familiar with the side effects, systemic toxicity and other complications of diagnosis and treatment.

Some local anesthesia such as head and neck injection, the incidence of serious adverse reactions is higher, and has nothing to do with the local anesthetic. Special attention should be paid to patients who are hospitalized with age or other serious illnesses. In order to reduce the potential risk of serious adverse reactions, before the implementation of anesthesia, should try to improve the patient's condition, drug dose should also be adjusted.

As ropivacaine in the liver metabolism, so severe liver disease patients should be used with caution, due to delayed drug excretion, repeated medication to reduce the dose. In general, patients with renal insufficiency who do not need to adjust the dosage with a single dose or short-term treatment. Chronic renal insufficiency patients with acidosis and hypoproteinemia, the possibility of systemic poisoning increased.

Epidural anesthesia can produce hypotension and bradycardia, such as pre-infusion expansion or the use of vascular drugs, can reduce the occurrence of this side effect, hypotension can occur once 5-10mg ephedrine intravenous treatment, if necessary Reproducible.

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Local anesthetics