Pain Relieving Local Anesthetic Drugs Prilocaine Hydrochloride CAS 721-50-6

Local Anesthetic Drugs Prilocaine hydrochloride For Relieving Pain CAS 721-50-6

Basic Info.

Prilocaine hydrochloride

CAS: 1786-81-8

Other name: Prilocaine hydrochloride; 2 - propylamine base - o C amide toluene hydrochloride; Prilocaine hydrochloride; Prilocaine hydrochloride

Molecular formula: C13H21ClN2O

EINECS: 217-244-0

Molecular Weight: 256.7716

Purity: 99%

Trademark: Pharmlab

Origin: China

Description

Propitocaine hydrochloride is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used forintravenous regional anaesthesia.

In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue.

Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or tertiary amine) and to hydrophobic group (aromatics) on the other side.

Local anesthetics, long duration, lower toxicity, chemicals that are also small Suitable for epidural anesthesia, block anesthesia and infiltration anesthesia, etc.

Introduction

Prilocaine hydrochloride, white crystalline powder, odorless, slightly bitter taste of bitter taste. Melting point 167 ~ 168 ℃. Soluble in water, ethanol, slightly soluble in chloroform. For local anesthetics, the mechanism of action with lidocaine, the intensity of action, the effect is also very similar to the speed of time to maintain a long, less toxic, small accumulation. Clinical for a variety of surgical infiltration anesthesia, epidural anesthesia, conduction anesthesia. A maximum dosage of 60mg, infiltration anesthesia with 0.5% to 1% solution; 2%, 3% solution for nerve block anesthesia and epidural anesthesia. Children should be prescribed.

Pharmacokinetic

Rapid absorption after the treatment, and all the body organs, can enter into the fetal circulation through the placental barrier, metabolism of drugs in the body from the kidneys, after very few prototype drug after bile and urine.

Side effect

prilocaine to drug overdose can cause degeneration of hemoglobin.

Notes

To prohibit excessive, anemia and denaturation of hemoglobin disease patients disabled prilocaine anesthesia, whether congenital or spontaneous patients disabled, disabled, maternal pregnant.

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