Healthy Local Anesthetic Drugs Procaine Hydrochloride For Anti - Inflammatory

Healthy Local Anesthetic Drugs Procaine Hydrochloride For Anti-Inflammatory

Quick Detail:

Product Name : Procaine Hydrochloride

Synonym: Aminocaine, anadolor, anesthesol, anestil, atoxicocaine, Benzoicacid,4-amino-,2-(diethylamino)ethylester,monohydrochloride, benzoicacid,p-amino-,2-(diethylamino)ethylester,monohydrochloride

Appearance: white crystalline powder

Purity: 99.9%

CAS: 51-05-8

Molecular formula: C13H21ClN2O2

Molecular weight: 72.77

Storage: Shading, confined preservation

Usage: Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.

Trademark: Pharmlab

Origin: China

Introduction

Procaine hydrochloride is a salt of the compound Procaine. Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), Procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit nicotinic acetylcholine receptors. Procaine is available alone (sc-296134) and in its salt form as Procaine HCl (sc-250776).

Description

Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.

White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.

The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.

The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β-naphthol, generating azo compounds scarlet.

Application

Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.

Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.

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