CAS 137525-51-0 Pentadecapeptide BPC 157 For Organic Muscle Rebuilder

Human Growth Hormone Peptide Pentadecapeptide BPC 157 For Organic Muscle Rebuilder

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BPC 157

Alias: Pentadecapeptide

CAS:137525-51-0

Sequence: Bpc 15, Bpc-157, Booly protection compound 15

MF:C62H98N16O22

MW:1419.53552

Purity:99%

Specification:2mg/vial

Appearance:White Lyophilized Powder

Packing:As requirments

Origin: China

Trademark: Pharmlad

Export Markets: Global

>>>Description

BPC 157 (Body Protection Compound-157) is a pentadecapeptide made up of 15 amino acids,it is a partial sequence of body protection compound that is discovered in and isolated from human gastric juice.BPC 157 enhances the healing of wounds, including tendons wounds such as transected Achilles tendons of rats,it significantly increased the survival of cells under oxidative stress and accelerated the dispersal of the fibroblasts in culture dishes in a dose-dependent manner.And BPC 157 also increases the probability of a cell surviving under oxidative stress. These actions are probably mediated by the activation of the proteinic FAK-paxillin pathway.

BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models.In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect.In addition, it significantly facilitates the healing of bone fracture in rats.This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect.BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.

FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts.Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins.The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.

>>>Information

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H(2)O(2) stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.

>>>Appilication

BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models,it may become an important therapeutic tool for the treatment of inflammatory bowel disease.BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect.And it significantly facilitates the healing of bone fracture in rats,exhibits an osteogenic effect significantly improving the healing of segmental bone defect.BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle,significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay.

Because BPC 157 has proven to be isolated from gastric juices, it should not be a surprise to find that various scientific studies that have been conducted on animal test subjects have been able to pinpoint several links between the peptide's presence and digestive tract functionality. Specifically, it has been determined that BPC 157 exhibits the capacity to regulate and control the manner in which the digestive tract can operate.

One of the ways that BPC 157 accomplishes this is through safeguarding the endothelium, which is the thin layer of cells that line the blood vessels' interior surface. Another way the peptide carries out regulatory function is by being a key factor in the process of angiogenesis; that is, the process in which new blood vessels are formed from pre-existing blood vessels.

This latter process is further bolstered by BPC 157's ability to form granulation tissue; this term references the new connective tissues and tiny blood vessels that develop on the surface of wound, thus making the peptide an important piece to the overall wound healing process. Further studies have also shown that the peptide's inherent functionality allows it to contain anti-inflammatory properties. Additionally, these studies have determined that BPC 157 can also help in the regulation and control of blood flow throughout an animal test subject's gastro-intestinal tract.

>>>COA

>>>Storage

stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C.

>>>Benefits

- Burn treatment.

- dramatic fast recovery from muscle tears.

- tendon to bone healing - increased ligament healing.

- has a variety of protective effects on the organs.

- human trials demonstrate healing and prevention of stomach ulcers.

- help repair some liver damage after prolonged chronic alcohol exposure.

- no adverse reactions have been seen in human trials.

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