MGF 2 Mg/Vial Human Growth Hormone Peptide For Growing Muscle CAS 12020-86-9

Human Growth Hormone Peptide MGF 2 Mg/Vial For Growing Muscle

Basic Info.

Name: MGF

CAS No: 12020-86-9

MW: 2868.19

Mf: C121H199N40O40

Appearance: White Freeze-Dried Powder

Sotre at: Cool Dry Place

Purity(HPLC): 97.30%

Packing: Aluminum Foil Bag

Standard: USP/BP

Export Markets: Global

Trademark: Pharmlad

Origin: China(Mainland)

WHAT IS MGF?

MGF was suggested to play a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. Included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage (Dluzniewska et al. 2005). One such failure is called sarcopenia. It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.

Mechano Groth Fact (MGF) also known as IGF-1Ec is a groth fact/repair factor that is derived from exercised or damaged muscle tissue. It's called MGF as IGF-IEa is a bit of a mouthful and harder to identify amongst the othervariants.

What makes MGF special is its' unique role in muscle growth. MGF has the ability to cause wasted tissue to grow and improve by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth. MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-1 receptor domain which, in turn, increases protein synthesis turnover; therefore, if used correctly it can improve muscle mass over time.

Application

Mechano growths factors (MGF) is a novel splice variant of the IGFS-1, also known as IGFS-1 Ec in humans and IGFS-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage of muscle growth tissue. The C-terminal peptide of the MGF is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame. In which a specific C-terminal sequence (E-domain) is encoded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule.

Action

When mechanical overload is introduced to a muscle , the IGFS-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGFS-1Ec . This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGFS-1 into MGF, production then switches towards producing a systemic release of IGFS-1Ea from the liver, which also upregulates protein synthesis as well.MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

COA

HOW TO USE MGF

When you train, what happens to your muscles is they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant. The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die.

As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair, if the cells are not repaired they die and your muscles get smaller and weaker. In muscle tissue, the pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.

Now, with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. In terms of dosages, 200mcg bi-laterally is the very best choice of dosing in muscles trained.

The only problem with MGF, and this is the reason I don't like it, is that it has such a short half life, just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn’t been damaged. That's why, for me personally, I think the best option is PEG MGF.

Nevertheless, MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is EXTREMELY anabolic.

MGF differs from the second variant IGF-IEa as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle; in other words, it is more anabolic and longer acting than the systematic release of the second MGF liver variant.

So just think of MGF as a highly anabolic variant of igf. After you have trained, the IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention.

In rats, some studies have shown muscle mass increases of 20 percent from a single MGF injection, but somehow I think many of these studies are not accurate, however the potential is undeniable. 

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