100% Safe USA Warehouse Supply 99.9% Purity Phenacetin Powder CAS 62-44-2

100% Safe Shipment USA Warehouse Supply Popular 99.9% Purity Phenacetin Powder CAS 62-44-2

Phenacetin powder

Other names: phenacetin
Chemical name: 1-acetyl-p-phenylenedi
Formyl; 4-acetophenidine CAS: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
Analysis: 99.9%
Appearance: white powder or white crystalline powder, odorless, slightly bitter taste.

Solubility: The product is hardly soluble in water, slightly soluble in ether, slightly soluble in boiling water, and easily soluble in ethanol and chloroform. Soluble in concentrated sulfuric acid, the color is not obvious, and the nitric acid in the solution is orange yellow.
Drug category: Antipyretic and analgesic raw materials
Uses: Antipyretic analgesic, used to treat fever, headache, neuralgia, etc.

Deacription

Phenacetin  is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887.

Phenacetin was introduced in 1887 in Elberfeld, Germany by German company Bayer, and was used principally as an analgesic; it was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties.

Prior to World War One, Britain imported phenacetin from Germany. During the war, a team including Jocelyn Field Thorpe and Martha Annie Whiteley developed a synthesis in Britain.

Uses

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India. As a result, some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.

Due to low-cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.

Safety

Phenacetin, and products containing phenacetin, have been shown in an animal model to have the side effect and after-effect of carcinogenesis. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially urothelial carcinoma of the renal pelvis. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases. In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis, or dissolution of blood cells, while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement system.

Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis. This is a condition which results in destruction of some or all of the renal papillae in the kidneys.
One notable death that can possibly be attributed to the use of this drug was that of the aviation pioneer Howard Hughes. He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure.

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