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active pharmaceutical ingredients,
pharmaceutical grade steroids
Bulk Nootropics Selective Androgen Receptor Modulators Powder Coluracetam MKC -231 CAS 135403-81-9
|Coluracetam Molecular Formula||C19H23N3O3|
|Coluracetam Molecular Weight||341.4|
Coluracetam (BCI-540) is a nootropic drug of the racetam family.Coluracetam (formerly known as MKC-231) was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease.
Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown
Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system
Application & Effects
Oxiracetam has been cited in the medicine field as having benefits such as, increasing cognitive function and processing. As a racetam and ampakine, it has a similar method to other racetams in the family. It is considered to be slightly higher in potency than Piracetam.
Oxiracetam is an all-around potent nootropic. It is more potent than Piracetam and has been known to offer stimulating effects. Alternatively, it can have the opposite effects of causing fatigue which suggests that levels of choline may not be adequate in these individuals. Nevertheless, Oxiracetam is still a favorite nootropic for many and can be used by itself or stacked with other nootropics.
Oxiracetam affects production of acetycholine and glutamate - which are two key neurotransmitters in the brain. Acetycholine deals with the central and peripheral nervous systems. Increasing production of acetycholine appears to improve our body's ability to concentrate and make logical decisions. Glutomate is an amino acid that plays a part in memory formation.
Oxiracetam has been shown in trials to have potential benefits for sufferers of Alzheimer's Disease and dementia. One particular scientific study concerned Oxiracetam's effects on dementia patients. The patients were given Oxiracetam at standard doses (around 1-2 grams a day) for around six months. The patients achieved significantly higher test scores for logical performance, memory recall, attention span and concentration. Similar improvements have been observed in patients with exogenic post-concussive and organic brain syndromes. Indications from these studies suggest that Oxiracetam might in fact be a more effective treatment for dementia than Piracetam.
Since the study subjects were mainly rats, there isn't any recommended human dosages, but there is a general guideline for conversion.
In rats, the dosage ranged between 1 mg/kg and 10 mg/kg per day. By using allometric scaling, the dose becomes 2.9 mg/kg in humans, so the average dose should not exceed 203.5 mg daily for someone in a typical weight class.
There isn't very much information to indicate toxicity of Coluracetam, although doses given at the above increments showed no negative side effects. If you haven't used a nootropic before, you may develop headache after use, which is a common in first time users. By stacking the Coluracetam with Choline, you'll reduce this risk.
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