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CAS 137-58-6 Local Anesthetic Drugs Pharmaceutical Raw Materials Lidocaine

CAS 137-58-6 Local Anesthetic Drugs Pharmaceutical Raw Materials Lidocaine

    • CAS 137-58-6 Local Anesthetic Drugs Pharmaceutical Raw Materials Lidocaine
    • CAS 137-58-6 Local Anesthetic Drugs Pharmaceutical Raw Materials Lidocaine
  • CAS 137-58-6 Local Anesthetic Drugs Pharmaceutical Raw Materials Lidocaine

    Product Details:

    Place of Origin: China
    Brand Name: Pharmlab
    Certification: ISO 9001, USP,GMP
    Model Number: 137-58-6

    Payment & Shipping Terms:

    Minimum Order Quantity: 10g
    Price: negotiation
    Packaging Details: Well disguised package with safe new shipping method;As requested.
    Delivery Time: Shipment within 24 hours, 3 to 5 days arrived
    Payment Terms: Western Union, MoneyGram, T/T, bitcoin
    Supply Ability: Mass in stock
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    Detailed Product Description
    Product Name: Lidocaine CAS: 137-58-6
    Appearance: White Crystals Powder Purity: 99%
    Molecular Formula: C14H23ClN2O Molecular Weight: 270.8
    Solubility: Ethanol: 4 Mg/mL Shipping: EMS,HKEMS,EUB,ETK,FEDEX,DHL,UPS,Aramex,ETC
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    Local Anesthetic Drugs Pharmaceutical Raw Materials Lidocaine CAS 137-58-6

     

     

     

     

    Quick Detail

     

    Product Name

    Lidocaine

    Other Name

    2-(Diethylamino)-N-(2,6-dimethylphenyl) acetamide

    Assay (%)

    ≥99.5

    Odor

    Characteristic

    Color

    White crystalline powder

    Cas No.

    137-58-6

    Molecular Formula

    C14H22N2O

    Molecular Weight

    234.34

    Standard

    USP30


    Function

    Main functions are as follows:
    1.Local anesthetic.
    2. Treating Epilepsy.
    3. Treating Asthma.

    Applications

    Main applications are as follows:
    Applied in pharmaceuticalfields.

    Packing

    1kgor 5kg/bag, 25kg/drum

    Shelf Life

    24 months

    Storage

    Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.

     

    Product Description:

    Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.

    Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

    Product Applications:

    The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action.

    Epinephrine vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.[2] Lidocaine drops can be used on the eyes for short ophthalmic procedures.

    Relative insensitivity to lidocaine is genetic. In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.

    Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge

    Lidocaine crosses the blood-brain and placental barriers, presumably by passive diffusion.
    Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine. Approximately 90% of Lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2, 6-dimethylaniline.

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