|Place of Origin:||China|
|Certification:||ISO 9001, USP,GMP|
|Minimum Order Quantity:||10g|
|Packaging Details:||Well disguised package ; special way to EU|
|Delivery Time:||3~5 work days|
|Payment Terms:||Western Union, MoneyGram, T/T,Bitcoins|
|Supply Ability:||Mass in stock|
|Melting Point:||170-171 °C(lit.)||Storage Temp.:||Controlled Substance, -20°C Freezer|
|Product Categories:||Pharmaceutical Intermediates;Steroids;Metabolites & Impurities||Grade:||Pharmaceutical Grade|
strong nutrition supplements
Prohormone Powder Androstenedione For Treatment of Anorchia Replacement Therapy
Molecular Fomule: C19H2602
Molecular Weight: 286.41
Apperance: White Crystaline Powder
Usage: Testosterone precursor and metabolite with androgenic activity. Controlled substance (anabolic sterid)
Export Markets: Global
Androstenedione is naturally found in meat, some plants, and in the human body. In the 1970s, androstenedione was developed by East German researchers in order to increase performance in their athletes. Androstenedione, commonly known as andro, was not introduced into the United States markets until the mid-1990s.
Androstenedione is taken orally in a concentrated pill or capsule and is now available in a spray that can be administered under the tongue for quicker results. The spray can increase androstenedione blood serum levels in about a half an hour as apposed to the pill or capsule, which takes about 2 hours. The goal of the andro is to increase testosterone levels so athletes can train harder and recover in less time. The claim is that harder training would ultimately lead to a gain in muscle mass and power. Although this goal has not been proven that andro promotes muscle growth, studies have shown andro increases androstenedione, testosterone, and estrogen levels. The lack of short-term and long-term research is the reason for doubts about the actual physiological effects of the substance on the body, and any side effects that may be associated with androstenedione.
Androstenedione has a steroid-like structure, and some researches claim that it is a weak anabolic steroid. If androstenedione were to be classified as an anabolic steroid it would become restricted by the Anabolic Steroids Act of 1990 which states: that in order for a substance to be classified as an anabolic steroid it (1)must have a structure related to testosterone, (2)must have pharmacology related to testosterone, (3)the substance cannot be an estrogen, progestin, or corticosteroid, (4)the substance must promote muscle growth. The latter of the four requirements does not classify andro as an anabolic steroid. There is no concrete evidence that the substance does promote muscle growth. It has only been proved to raise levels of androstenedione, testosterone, and estrogens.
Mark McGwire made this product well known after admitting to using the product on his way to breaking the home-run record in 1998. McGwire had several homerun seasons comparable to that. Using this product does not guarantee to enhance performance.
In the body, it is produced by the adrenal glands and gonads from dehyroepiandrosterone (DHEA or 17- alpha-hydroxyprogesterone). DHEA is converted into androstenedione an the enzyme in the gonads. Androstenedione is a precursor of testosterone. Once the androstenedione is taken orally, it makes it into the liver where it is almost destroyed completely, the amount that survives combine with the enzyme 17 beta-hydroxysteroid dehydrogenase to make testosterone as shown in the figure below. Taking androstenedione orally can increase androstenedione blood serum levels over 300 percent after about 2 hours and remaining high for 4 hours. Studies have shown that androstenedione by itself does not produce increased muscle mass but once converted into testosterone in the liver, the elevated testosterone levels may lead to muscle mass gain, but not proven.
The problem with androstenedione is that it metabolizes quickly into estrogens, estrone and estradiol as shown in the figure. These two products can stay in the body for days as opposed to the androstenedione, which diminishes within hours. Estrogens have an opposite effect than testosterone; they suppress fat-loss and tissue healing. Estrogen levels can be monitored and managed by blood and saliva testing in order to be kept under control if using the product.
A study published by the American Medical Association (AMA), investigated the anabolic effects of orally taking androstenedione with men that had none or little weight training experience. The study focused on short-term effects of a single 100 mg dose followed by a longer term of 300 mg for an eight-week program of weight training. This study proved the androstenedione increased androstenedione, estrone and estradiol levels within the body. Luteininzing Hormone (LH), folical-stimulating hormone (FSH) which are involved in the production of testosterone within the body, was unaffected as were liver enzymes. This suggests that ingesting androstenedione would not affect the body in producing testosterone as in the case where elevated levels of testosterone may affect the self-production of the testosterone. The study only stated that androstenedione can produce elevated testosterone levels, and not that the levels of testosterone were not sufficient to produce enhanced performance.
Androstenedione is a direct precursor of testosterone and estrone. DHEA on the other hand has an indirect metabolic pathway to estrone, may produce lower estrogen levels, but will also not increase the levels of testosterone as andro does, and therefore may not yield as high of a muscle mass gain according to some researchers.
Simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroids, norethisterone, testosterone propionate in the middle Body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.
4-Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion of dehydroepiandrosterone to 4-Androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to 4-androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of 4-androstenedione, whether immediately or one step removed.
The production of adrenal 4-Androstenedione is governed by ACTH, whereas production of gonadal 4-Androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total 4-androstenedione(about 3 mg/day). After menopause, 4-androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Nevertheless, 4-androstenedione is the principal steroid produced by the postmenopausal ovary.
Advantages of using this product for the sole purpose of muscle gain are not known due to the lack of research in short-term and long-term studies. Many athletes claim that this product enhances muscle mass due to personal experience, but again that is not Proven yet. Marketers claim that taking androstenedione can boost testosterone levels up to 300% for about 3 hours.
There are no reported side effects of related to the ingestion of androstenedione. However, high doses of androstenedione can produce elevated testosterone levels. Some side effects from elevated testosterone levels are: enlargement of breasts, prostate and other glandular tissues, as well as risk of Glandular cancers, hair loss, water / salt retention, lower LDL levels (Low Density Lipoproteins), impotence, acne, oily skin, and increased sex drive.
Women can avoid using androstenedione because of available elevated testosterone levels. The high testosterone levels may lead to some longer lasting effects such as deep voice and increasing facial hair (beard), enlargement of genitals and other masculine characteristics.
4-AD was probably one of the most popular prohormones used before the ban of 2004, even though it is a rather wet compound because of its water retention. Hence, as mentioned above, it would most likely be used in a bulking cycle over a cutting cycle. Sadly, this compound is not available any more, and the closest alternative are the SARMS, which truly deserve a good portion of attention.
Pro hormones Powder
Epistane (Epithio / Havoc) (Epitiostanol)
Methoxygonadiene ( Max LMG)
Orastan-E (Stanozol THP)
Trenavar/ Trendione/ Celtitren
Methyl 1,4-AD (Methyl-1,4-androstadienediol)
4-Androstenediol ( 4-AD )
11-OXO (11-Ketotestosterone/ Adrenosterone )
17a-Methyl-1-testosterone ( M1T)
19 Tren X (Methyldienedione) (Estra-4,9-diene-3,17-dione)
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