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Tamoxifen Citrate Nolvadex Oral Anabolic Steroids For Bodybuilding And Breast Cancer

Tamoxifen Citrate Nolvadex Oral Anabolic Steroids For Bodybuilding And Breast Cancer

  • Tamoxifen Citrate Nolvadex Oral Anabolic Steroids For Bodybuilding And Breast Cancer
  • Tamoxifen Citrate Nolvadex Oral Anabolic Steroids For Bodybuilding And Breast Cancer
  • Tamoxifen Citrate Nolvadex Oral Anabolic Steroids For Bodybuilding And Breast Cancer
Tamoxifen Citrate Nolvadex Oral Anabolic Steroids For Bodybuilding And Breast Cancer
Product Details:
Place of Origin: China
Brand Name: Pharmlab
Certification: ISO 9001, USP,GMP
Model Number: 54965-24-1
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: negotiation
Packaging Details: Disguised package ; Foil bag
Delivery Time: 3-5 work days
Payment Terms: Western Union, MoneyGram, T/T, bitcoin
Supply Ability: Mass in stock
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Detailed Product Description
Prodcut Name: Tamoxifen Citrate Other Name: Nolvadex
CAS: 54965-24-1 Purity: >99%
Mf: C26h29no MW: 371.51
Trademark: Pharmlab Grade: Pharmaceutical Grade
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Anti Estrogen Steroid Tamoxifen Citrate Nolvadex for Bodybuilding and Breast Cancer

 

 

 

 

Quick detail

 

Prodcut Name: Tamoxifen Citrate

 

Other name: Nolvadex

 

Model NO.: CZG-ST50

 

Customized: Customized

 

Suitable for: Adult

 

Purity: >99%

 

CAS: 54965-24-1

 

Melting Point: 140-144 Degree Centigrade

 

MOQ: 10gram

 

Mf: C26h29no

 

Brand Name: Pharmlab

 

Transport Package: Alumiuim Foil or as Customer′s Requirement

 

Origin: China

 

Powder: Yes

 

Certification: GMP, ISO 9001, USP, BP

 

State: Solid

 

Grade: USP

 

Pack: Drum, Plastic Container

 

MW: 371.51

 

Export Markets: Global

 

Trademark: Pharmlab

 

Specification: USP

 

Grade: Pharmaceutical grade

 

 

 

 

 

COA

 

Product Name: Tamoxifen citrate
Synonyms: 1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene citrate;(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine,citrate(1:;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylaminecitrate(;2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin2-hydrox;ici46,474;kessar;noltam;tamofen
CAS: 54965-24-1
MF: C32H37NO8
MW: 563.64
EINECS: 259-415-2
Product Categories: Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;API's;Intracellular receptor;Steroid and Hormone;API;SOLTAMOX
Mol File: 54965-24-1.mol

 

 

 

 

 

Tamoxifen citrate Chemical Properties

 

mp 140-144 °C
storage temp. 2-8°C
Water Solubility slightly soluble
Merck 9048
CAS DataBase Reference 54965-24-1(CAS DataBase Reference)
EPA Substance Registry System Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1- butenyl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)(54965-24-1)

 

 

 

Safety Information

 

   
Risk Statements 45-60-61-22-64-36/37/38
Safety Statements 53-36/37/39-45-36-26
WGK Germany 3
RTECS KH2387000
HazardClass IRRITANT

 

 

 

 

 

Tamoxifen citrate Usage And Synthesis

 

Chemical Properties white to off-white powder
Usage estrogen antagonist, antineoplastic
Usage anti-estrogen, protein kinase C inhibitor, beneficial cardiovascular effects, bone cancer treatment, induces DNA adduct formation
Usage An antiestrogen with potent anti-cancer and PKC inhibitory activities
Biological Activity Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo . Also high affinity agonist at the membrane estrogen receptor GPR30.

 

 

 

 

What is Tamoxifen Citrate?

 

Tamoxifen Citrate (Nolvadex) Is an estrogen competitive antagonist and a nonsteroidal antiestrogen drug. It can compete with estrogen (estradiol) to bind to estrogen receptors in breast cancer cells, inhibit the effect of estrogen on cancer cells, inhibit tumor cell growth and development, and show anticancer effects. In clinical practice, tamoxifen citrate is commonly used to treat various types of breast cancer, particularly in women with postmenopausal breast cancer with estrogen receptor and progesterone receptor positive and with low prostate specific antigen levels.

 

 

 

Mechanism of action

 

TCT has a cis-trans isomer, its cis-isomer has a weak estrogenic effect, whereas the trans isomer has an antiestrogen effect. When the early application of tamoxifen or the presence of low concentrations, it binds to the estrogen receptor (ER) in the cytoplasm, exhibiting a weaker estrogenic effect. TCT into the nucleus, can inhibit the nuclear ER transcription and synthesis, resulting in lasting anti-estrogen effect.

 

It has been found that many of the new features of TCT are associated with mechanisms of action beyond their competitive estrogen receptor-membrane regulatory mechanisms. TCT as a membrane modifier, can reduce cell cycle. On this basis, TCT can also act as an antioxidant to protect the cell membrane and human LDL from oxidative damage.

 

 

 

 

 

Pharmacodynamics of Tamoxifen Citrate

 

TCT oral absorption is slow, plasma concentration in 3 ~ 6 hours to reach the peak. After absorption of the liver, tamoxifen citrate metabolism to N-desmethyl tamoxifen, its activity and tamoxifen citrate similar. The half-life of tamoxifen citrate is 5 to 7 days and its metabolite N-desmethyl tamoxifen is 7 to 14 days.

 

Animal experiments show that tamoxifen citric acid and N-desmethyl tamoxifen are circulating in a wide range of enteric liver. For a single oral dose of 20 mg TCT, the plasma concentration peak was about 40 ng / ml (range 67-183 ng / ml) and 336 ng ml (range: 148 to 654 ng / ml). The steady-state plasma concentration of tamoxifen citrate, which requires three to four weeks of continuous administration, generally requires the continuous administration of N-methyltamethoxamine for 3 to 8 weeks. Tamoxifen citrate and most other metabolites are mainly excreted in the feces, and a small fraction of the metabolites excreted in the urine.

 

 

 

 

Clinical application of Tamoxifen Citrate

 

1. Breast cancer treatment

2. Prevention of breast cancer.

 

 

 

Anti-tumor and anti-multidrug resistance.

 

Methomorphine citrate reduces the concentration and activity of cancer transfer promoters and various activating enzymes, thereby inhibiting or hindering the growth and metastasis of cancer cells, by reducing membrane permeability and enhancing the rigidity of the intercellular binding sites.

 

In addition, it promotes the secretion of negative growth factor-TGF-G, which inhibits the proliferation of cancer cells by inhibiting the proliferation of cancer cells, and inhibits the oxidative damage of DNA bases caused by hydrogen production from human neutrophils. In addition to breast cancer, there are other malignant tumor treatment and prevention, for the treatment of brain tumors, liver cancer, prostate cancer. In addition, tamoxifen citrate can reduce the membrane release of membrane P170 glycoprotein membrane, improve the intracellular effective concentration of cytotoxic drugs and reduce drug resistance.Heart protection

 

 

 

 

 

The use Tamoxifen Citrate

 

For the treatment of advanced and recurrent breast cancer and ovarian cancer. Anti-estrogen with potent anti-cancer and PKC inhibitory activity

 

 

 

 

 

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