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SR9011 For Increasing Fitness Endurance CAS 1379686-29-9 Weight Loss Steroids

SR9011 For Increasing Fitness Endurance CAS 1379686-29-9 Weight Loss Steroids

  • SR9011 For Increasing Fitness Endurance CAS 1379686-29-9 Weight Loss Steroids
  • SR9011 For Increasing Fitness Endurance CAS 1379686-29-9 Weight Loss Steroids
SR9011 For Increasing Fitness Endurance CAS 1379686-29-9 Weight Loss Steroids
Product Details:
Place of Origin: China
Brand Name: Pharmlab
Certification: ISO 9001, USP,GMP
Model Number: 1379686-29-9
Payment & Shipping Terms:
Minimum Order Quantity: negotiation
Price: negotiation
Packaging Details: EMS,HKEMS,FEDEX,DHL,TNT,Aramex,ETC
Delivery Time: 3-5 work days
Payment Terms: Western Union, MoneyGram, T/T, bitcoin
Supply Ability: Mass in stock
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Detailed Product Description
Product Name: SR9011 CAS: 1379686-29-9
Purity: 99% Grade: Pharmaceutical Grade
Shipping Methods: EMS,HKEMS,FEDEX,DHL,TNT,Aramex,ETC Shipping Policy: 100% Free Resend Policy
High Light:

selective androgen receptor modulators

,

sarms anabolic steroids

SR9011 For Increasing Fitness Endurance CAS 1379686-29-9 Weight Loss Steroids

 

Quick Details

 

SR9011


CAS No.: 1379686-29-9
Molecular formular: C20H24ClN3O4S
Appearance: White powder
Purity: 99%
Application: SR9011 increase exercise endurance and loss weight.
Usage:reduce mass fat
Chemical structure:

Sr9011 SARMS Bodybuilding Supplements CAS 1379686-29-9 For Fitness Nutrition

 

 

 

SR9011 Powder Description


SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.

 

SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.

 

The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia.

 

These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

 

SR9011 Usage


A new compound called SR9011 increases metabolism, fat burning, and muscle growth in the lab.
Scientists at The Scripps Research Institute (TSRI) have successfully tested a drug, called SR9011,
in mice that kickstarts metabolism and results in increased muscle development.
Essentially, it's an exercise regime in a pill.

SR9011 alters the metabolic profile of skeletal muscle in a manner similar to the changes observed [in]
animals [that] are endurance trained. Basically, the drug sends a signal to the muscle to tell it to modify
its metabolism.

Half of the mice studied showed improved running endurance in terms of both time and distance. What was clearly interesting was that a small, drug-like molecule could increase metabolic rate in skeletal muscle and increase exercise endurance

 

In Vitro


SR9011 dose-dependently increases the REV-ERB-dependent repressor activity assessed in HEK293 cells expressing a chimeric Gal4 DNA Binding Domain (DBD) - REV-ERB ligand binding domain (LBD) α or β and a Gal4-responsive luciferase reporter (REV-ERBα IC50=790 nM, REV-ERBβ IC50=560 nM). SR9011 potently and efficaciously suppresses transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50=620 nM).

 

SR9011 suppresses the expression ofBMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner SR9011 suppresses proliferation of the breast cancer cell lines regardless of their ER or HER2 status. SR9011 appears to pause the cell cycle of the breast cancer cells prior to M phase. Cyclin A (CCNA2) is identified as a direct target gene of REV-ERB suggesting that suppression of expression of this cyclin by SR9011 may mediate the cell cycle arrest. Treatment with SR9011 results in an increase in cells in the G0/G1 phase and a decrease of cells in S and G2/M phase suggesting that activation of REV-ERB may be resulting in decreased transition from G1 to S phase and/or from S to G2/M phase.

 

SR9011

 

SR9011 For Increasing Fitness Endurance CAS 1379686-29-9 Weight Loss Steroids 1

 

In Vivo

 

SR9011 displays reasonable plasma exposure, thus, the expression of REV-ERB responsive genes is examined in the liver of mice treated with various doses of SR9011 for 6-days. The plasminogen activator inhibitor type 1 gene (Serpine1) is a REV-ERB target gene and displays dose-dependent suppression of expression in response to SR9011. The cholesterol 7α-hydroxylase (Cyp7a1) and sterol response element binding protein (Srepf1) genes have also been shown to be responsive to REV-ERB and are dose-dependently suppressed with increasing amounts of SR9011. After 12 days in D:D conditions mice are injected with a single dose of SR9011 or vehicle at CT6 (peak expression of Rev-erbα).

 

Vehicle injection causes no disruption in circadian locomotor activity. However, administration of a single dose of SR9011 results in loss of locomotor activity during the subject dark phase. Normal activity returns the next circadian cycle, consistent with clearance of the drugs in less than 24h. The SR9011-dependent decrease in wheel running behavior in the mice under constant darkness conditions is dose-dependent and that the potency (ED50=56 mg/kg) is similar to the potency of SR9011-mediated suppression of a REV-ERB responsive gene, Srebf1 , in vivo (ED50=67mg/kg).

 

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Packaging & Delivery

 

Export forceful: Our products have exported to Germany, Norway, Poland,

Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.

 

High pass rate: Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed.

 

Fast delivery: Most of powders are in stock, Chargeable samples are available,

Could be shipped out within 24hours.High quality, good price, fast and safety

 

Flexible price: A discount would be given when you make a large order.

 

Good after-sale service:Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible

 

We have professional team for package and shipment. Special way to ship 100 grams to 100kg powders at one time to your country. Fast and discreet delivery. Shipment by DHL, TNT, FEDEX, HKEMS, UPS, etc.

 

shipment could be arranged for customs pass Guaranteed.

 

Years old factory: Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.

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