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Pirfenidone High Purity Pharmaceutical Raw Materials Anti Fibrosis Piresupa

Pirfenidone High Purity Pharmaceutical Raw Materials Anti Fibrosis Piresupa

  • Pirfenidone High Purity Pharmaceutical Raw Materials Anti Fibrosis Piresupa
  • Pirfenidone High Purity Pharmaceutical Raw Materials Anti Fibrosis Piresupa
Pirfenidone High Purity Pharmaceutical Raw Materials Anti Fibrosis Piresupa
Product Details:
Place of Origin: China
Brand Name: Pharmlab
Certification: ISO 9001, USP,GMP
Model Number: 53179-13-8
Payment & Shipping Terms:
Minimum Order Quantity: negotiation
Price: negotiation
Packaging Details: Disguised package ; Foil bag
Delivery Time: 3-5 work days
Payment Terms: Western Union, MoneyGram, T/T, bitcoin
Supply Ability: Mass in stock
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Detailed Product Description
Name: Pirfenidone Other Name: 5-Methyl-N-phenyl-2-1H-pyridone
Grade: Pharmaceutical Package: Well Disguised Package ;Foil Bag
Purity: 99% Appearance: White Powder
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Pirfenidone High Purity Pharmaceutical Raw Material Anti Fibrosis Piresupa

 

What is pirfenidone?


Pirfenidone is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). IPF causes scar tissue to form deep within your lungs. The scar tissue thickens and becomes stiff or thick over time, which can make it harder for your lungs to work. Decreased lung function can make it hard for you to breathe. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen.


The cause of IPF is often unknown, but this condition is a progressive disease that can be fatal. Pirfenidone is not a cure for IPF, but this medicine may slow the progress of this disease.


Pirfenidone may also be used for purposes not listed in this medication guide.

 

Quick Detail

 

Product name Pirfenidone
Other name 5-Methyl-N-phenyl-2-1H-pyridone
CAS 53179-13-8
MF 185.22
MW; 483.95
Molecular structure Pirfenidone High Purity Pharmaceutical Raw Materials Anti Fibrosis Piresupa 0
Assay 99%
Appearance White crystal powder
Usage Treatment of Pulmonary Fibrosis

 

Description

 

In the Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis (ASCEND) study, a randomized, double-blind, placebo-controlled trial, we aimed to confirm the effect of pirfenidone on disease progression in patients with idiopathic pulmonary fibrosis. Our design modifications with respect to the CAPACITY trial included the implementation of centralized procedures for diagnosis, spirometry, ,

 

Pirfenidone is an oral antifibrotic therapy that has been evaluated for the treatment of idiopathic pulmonary fibrosis in three phase 3, randomized, controlled trials. One of these trials was conducted in Japan and involved 275 patients. It was followed by two multinational studies, Clinical Studies Assessing Pirfenidone in Idiopathic Pulmonary Fibrosis: Research of Efficacy and Safety Outcomes, that were conducted in the United States, Europe, and Australia and involved 779 patients.7,8 In the Japanese trial, pirfenidone reduced the decline in vital capacity at week 52 and improved progression-free survival. In the multinational trials, the primary end point of change from baseline to week 72 in the percentage of the predicted forced vital capacitywas met in study 004 but not in study 006, prompting U.S. regulatory authorities to request an additional trial to support the approval of pirfenidone.

 

Applications

 

Pirfenidone has proven antifibrotic and anti-inflammatory properties in various in vitro systems and animal models of pulmonary fibrosis, although its precise mechanism of action remains unclear. It attenuates fibroblast proliferation, production of fibrosis-associated proteins and cytokines, and the increased biosynthesis and accumulation of extracellular matrix in response to cytokines such as transforming growth factor-β. It is also shown to slow tumor cell proliferation by inhibiting fibroblast growth factor, epidermal growth factor and platelet-derived growth factor.

 

Idiopathic pulmonary fibrosis is characterized by radiographically evident interstitial infiltrates predominantly affecting the lung bases and by progressive dyspnea and worsening of pulmonary function. No therapy has been clearly shown to prolong survival. The current strict definition of idiopathic pulmonary fibrosis provides a new focus for basic and clinical research that will improve insight into the pathogenesis of this disorder and stimulate the development of novel therapies.

 

COA

 

Product Pirfenidone Batch No. 150301
Man.date Mar.30,2015 Expiry date Mar.29,2018
Testing date Mar.30,2015 Report date Mar.31,2015
Quantity 30kg Quality standard Enterprise Standard
Items Specifications Results
Appearance A little yellow to white powder Pass
Identification IR As stipulation Pass
Loss on drying No more than 1.0% 0.22%
Heavy metal No more than 20ppm Pass
Sulphated ash No more than 0.2% 0.10%
Any impurity No more than 0.5% 0.13%
Total impurity No more than 1.0% 0.30%
Assay 99.0%~101.0% 99.70%
Conclusion Qualified

 

How should I take pirfenidone?


(1)Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using pirfenidone.
 

(2)Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than

recommended.
 

(3)Pirfenidone should be taken with food to help decrease nausea or dizziness.
 

(4)Pirfenidone is usually taken 3 times per day. Your dose needs will change over the first 15 days of your treatment.
 

For the first week, you will take only 1 capsule at a time.
 

During the second week, you will take 2 capsules at a time.
 

From the third week on, you will take 3 capsules at a time.
 

You must follow this 2-week "dose escalation" schedule when you start taking pirfenidone, or if you start taking the medicine again after not taking it for 14 days or longer. Follow your doctor's dosing instructions very carefully.

 

Function


1. Idiopathic pulmonary fibrosis degeneration


2. Liver Fibrosis


3. Renal fibrosis disease


4. Multiple Sclerosis


5. Myocardial fibrosis


6. Neoplastic diseases: neurofibroma, leiomyoma, and malignant gliomas.


7. Prevention of fibrosis after the organ transplant.


8. Rheumatoid arthritis.

 

Prfenidone

 

Pirfenidone High Purity Pharmaceutical Raw Materials Anti Fibrosis Piresupa 1

 

Pirfenidone High Purity Pharmaceutical Raw Materials Anti Fibrosis Piresupa 2

 

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Competitive Advantage

 

1. Our company is a professional production leading factory in China in pharmaceutical area of many years.

 

Delivery areas of our products: US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on.

 

Payment method: T/T, Western union, Moneygram, bitcoin etc.

 

2. Discreet package. The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration.

 

3. Top quality. High quality guarenteed, once any problem is found, the package would be reshipped for you.

 

4. Security Shipping: Shipping by express (FedEx, UPS, DHL, EMS), by air. The most professional forwarder would be recommanded for you.

 

5. We have stock, so we can delivery quickly at the very day when receive the payment.

 

6. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.

 

7. A discount would be given when you make a large order.

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