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Pharmaceutical Raw Materials Phenacetin for Pain Relieving CAS 62-44-2

Pharmaceutical Raw Materials Phenacetin for Pain Relieving CAS 62-44-2

  • Pharmaceutical Raw Materials Phenacetin for Pain Relieving CAS 62-44-2
  • Pharmaceutical Raw Materials Phenacetin for Pain Relieving CAS 62-44-2
Pharmaceutical Raw Materials Phenacetin for Pain Relieving CAS 62-44-2
Product Details:
Place of Origin: China
Brand Name: Pharmlab
Certification: ISO 9001, USP,GMP
Model Number: 62-44-2
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: negotiation
Packaging Details: Disguised package ; Foil bag
Delivery Time: 3-7 work days
Payment Terms: Western Union, MoneyGram, T/T, bitcoin
Supply Ability: Mass in stock
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Detailed Product Description
Product Name: Phenacetin Whatsapp: 8618186204104
Usage: Analgesic, Antipyretic Shiping: EMS,HKEMS,FEDEX,DHL,TNT,Aramex,etc
Package: Foil Bag; Well Disguised Package Shipping Policy: 100% Free Resend Shipping
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Phenacetin Pharmaceutical Raw Materials for Pain Relieving CAS 62-44-2

 

 

Quick Detail:

 

Product name: Phenacetin
CAS: 62-44-2
EINECS Number: 200-533-0
Formula: C10H13NO2
MW: 179.2157

MS:

Pharmaceutical Raw Materials Phenacetin for Pain Relieving CAS 62-44-2 0

Assay: 99%
Appearance: White or almost white crystalline powder
Density: 1.099g / cm3
Melting point: 133-138 ℃
Boiling point: 355.1 ° C at 760 mmHg
Flash Point: 168.5 ° C
Water-soluble: 0.076 g / 100 mL
Vapor Pressure: 3.21E-05mmHg at 25 ° C
Uses: Anti-inflammatory drugs

 


Descriptions:

 

Phenacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenacetin.

 

Phenacetin is a white crystalline powder with the chemical composition C10H13NO2. It was first developed by Harmon Northrop Morse in 1878. In addition to its pain-reducing properties, it also has been used as a fever-reducer, a treatment for rheumatoid arthritis and a treatment for intercostal neuralgia, a rare disorder that causes pain in the nerves around the ribs. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities.

 


Applications:

 

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).

 

It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

 

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.

 

Pharmaceutical Raw Materials Phenacetin for Pain Relieving CAS 62-44-2 1

 

Background and Benefits:

 

Phenacetin, introduced in 1887, was used principally as an analgesic, and was the first NSAID and fever reducer to go on the market. Typical doses of 300mg to 500mg a day result in an analgesic effect. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action of the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type), intercostal neuralgia, and some forms of ataxia.

 

Phenacetin, and products containing phenacetin have been shown in an animal model to be carcinogenic. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially transitional cell carcinoma of the renal pelvis. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases.


In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to Phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement cascade.

 

Phenacetin was widely used until the third quarter of the twentieth century, but was then largely replaced by non-carcinogenic drugs. Some branded phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Both propyphenazone and paracetamol are metabolites of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

 

In Norway phenacetin is sold perscription over-the-counter with caffeine in a preparation know as Fenazon-Koffein. One tablet of Fenazon-Koffein contains 500mg phenacetin and 100mg caffeine along with filler products such as glucose.

 

COA

 

Items of analysis Specification Results
Description White or almost white crystalline powder Compliance
Identification Should be positive reaction Compliance
Melting point 134ºC to 136ºC 135.5ºC
4-chloroacetanilide Should comply with standard Compliance
P-Phenetidine Should comply with standard Compliance
Sulphated ash ≤0.1% 0.07%
Assay ≥99% 99.1%
Conclusion Qualified

 

 

How It Works:

 

Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.

 

It is metabolised in the body as paracetamol (acetaminophen).

 

 

Dosage:

 

Analgesic mixtures containing phenacetin were previously marketed as tablets or capsules containing between 150 and 300 mg phenacetin. Common combinations were: 150 mg phenacetin, 230 mg aspirin, and 15 or 30 mg caffeine; or 150 mg phenacetin, 230 mg aspirin, 30 mg caffeine, and 8, 15, 30, or 60 mg codeine phosphate. Phenacetin alone was also available in 250 and 300 mg doses as tablets, and up to 500 mg doses as powder. The usual dose was 300 mg 4-6 times per day, and the daily dose was not to exceed 2 g.

 

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HOW TO MAKE AN ORDER?

 

1. Tell us what you need ( use for what/product name & quantity ), you will get an advice and a quotation.


2. Full payment would be done once we come to an agreement on all details .


3. Your goods will be sent out within 24 hours after payment , tracking number available.


4. The goods will reach you in 3~7 days.


WHY CHOOSE US?

1. High quality: Our factories are professional in raw powder production with experience over 10 years. Having good reputation all over the world, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.

 

2. Competetive price: All powders are factory directly supplied, it's factory price and negotiable.

 

3. Fast and safe delivery: Your goods will be sent out within 24 hours after payment, tracking number available, customs pass rate ≥99%.

 

4. Good pre&after-sales service: Any problem please feel free to contact us, we will always be online for you.

 

High quality, competetive price, fast and safe delivery, good service,that's us! Welcome to contact!

 

 

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