|Place of Origin:||China|
|Certification:||ISO 9001 ,USP,GMP|
|Minimum Order Quantity:||10grams|
|Packaging Details:||Disguised pacakge ; Foil bag|
|Delivery Time:||3-5 work days|
|Payment Terms:||T/T, Western Union, MoneyGram, Bitcoin|
|Supply Ability:||Mass in stock|
|Appearance:||White Powder||Grade:||Pharmaceutical Grade|
selective androgen receptor modulators,
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SARMs Raw Powder SR9011 Powder For Muscle Building Supplements
Appearance: White Powder
Packaging: Well Disguised Package Or As Your Requirement
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Delivery: 3-5 Days To Your Detailed Address
Policy: Reship And Discount
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.
The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular health and preventing metabolic diseases.
Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increase denergy expenditure.Treatment of diet-induced obese mice with a SR9011 decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia.
There's no way to sugarcoat it-though many have tried-maintaining a healthy weight can be difficult. Because it's hard, many have tried "miracle" weight-loss pills and other quick fixes for something that ultimately requires a lifestyle change. Many over-the-counter diet and weigh-loss pills are unregulated and may contain dangerous ingredients. SR9011, however, isn't like appetite suppressants, laxatives, or "fat blockers." And you won't find SR9011 in the ingredient lists of protein powders or exercise supplements.
The difference between SR9009 and other diet pills is in its chemistry. SR9011 is not an appetite suppressant-as many weight-loss drugs are-and directly works by increasing the metabolic rate of muscle. Your metabolism speeds up and slows down naturally during the day, meaning that sometimes food is used for energy and sometimes it's stored as fat. By re-synching a dysfunctional metabolic clock, SR9011 ensures that food and excess fat are used as energy.
SR9011 is one of a pair of compounds developed at TSRI by Burris and his team. The drug binds to Rev-erb,a natural protein in the body that influences lipid and glucose metabolism in the liver, inflammatory responses, and fat-storing cells. By binding to Rev-erb, SR9011 can kickstart metabolism with another pleasant side-effect: increased muscle strength.
|Appearance||An odorless, almost white or white powder||pass|
|Identificaton||The retention time of the major peak is confirm to the RS||pass|
|Loss on Drying||Not more than 0.5%||0.33%|
|Assay(HPLC)||Not less than 99.0%||99.59%|
|Ignition residue||Not more than 0.1%||pass|
|Heavy metal||Not more than 20 ppm||pass|
A new compound called SR9011 increases metabolism, fat burning, and muscle growth in the lab. Scientists at The Scripps Research Institute (TSRI) have successfully tested a drug, called SR9011, in mice that kickstarts metabolism and results in increased muscle development.
Essentially, it's an exercise regime in a pill.
SR9011 alters the metabolic profile of skeletal muscle in a manner similar to the changes observed [in] animals that are endurance trained. Basically, the drug sends a signal to the muscle to tell it to modify its metabolism.
Half of the mice studied showed improved running endurance in terms of both time and distance. What was clearly interesting was that a small, drug-like molecule could increase metabolic rate in skeletal muscle and increase exercise endurance
How to Use
In vitro: SR9011 was used at 5-10 µM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
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