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Paracetamol 4-Acetamidophenol Superb Analgesic Pharmaceutical Intermediate CAS 103-90-2

Paracetamol 4-Acetamidophenol Superb Analgesic Pharmaceutical Intermediate CAS 103-90-2

  • Paracetamol 4-Acetamidophenol Superb Analgesic Pharmaceutical Intermediate CAS 103-90-2
  • Paracetamol 4-Acetamidophenol Superb Analgesic Pharmaceutical Intermediate CAS 103-90-2
Paracetamol 4-Acetamidophenol Superb Analgesic Pharmaceutical Intermediate CAS 103-90-2
Product Details:
Place of Origin: China
Brand Name: RAWSGEAR
Certification: ISO 9001, USP,GMP
Model Number: 103-90-2
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Minimum Order Quantity: negotiation
Price: negotiation
Packaging Details: Disguised package ; Foil bag
Delivery Time: 3-5 work days
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Detailed Product Description
Product Name: Paracetamol CAS: 103-90-2
Appearance: White Crystal Or Crystalline Powder Shipping Methods: EMS,HKEMS,FEDEX,DHL,TNT,Aramex
Shipping Policy: 100% Free Resend Policy Email: RAWSGEAR
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Paracetamol 4-Acetamidophenol Superb Analgesic Pharmaceutical Intermediate CAS 103-90-2

Quick details

 

product Name Paracetamol
Alias 4-Acetamidophenol;4'-HYDROXYACETANILIDE;4-HYDROXYACETANILIDE;ACETYL-P-AMINOPHENOL
CAS 103-90-2
EINECS 203-157-5
M.F. C8H9NO2
M.W. 151.16
Product Category Pharmaceutical raw materials and intermediates
Product content 98.0% -102.0%
Quality Standard cp2000/bp98/usp23
Packing Specification 25KG / plastic woven bag or 25KG / fiber drum
Appearance white crystal or crystalline powder
Usage Antipyretic analgesic bulk drugs

 

Paracetamol Descriptions


1.Paracetamol is well absorbed in the gastrointestinal tract. Oral bioavailability is dose dependant: with larger doses, the hepatic first pass effect is reduced due to overwhelming of the liver enzymatic capacity; and therefore, bioavailability is increased.

2.Rectal administration of paracetamol is also feasible. In this case, bioavailability is inconsistent and in overall reduced, due to incomplete dissolution of the suppository in the rectum. The absorption rate through this route of administration is elongated.

3.Paracetamol is distributed throughout the body fluids in a homogeneous way. The analgesic activity is attributable to the small fraction that penetrates into the brain. Paracetamol given at therapeutic doses binds to plasma proteins at less than 20%. In case of intoxication, this proportion may increase to up to 50%.

4.Paracetamol is essentially metabolized in the liver by conjugation with glucuronic acid (55%) and sulfuric acid (35%). Hepatotoxic metabolites are produced in small amounts by the cytochrome P450 (isoenzyme CYP2E1). In the therapeutic plasma concentration range, this metabolite is detoxified by conjugation with glutathione. In case of intoxication the amount of this toxic metabolite increases and outweighs the amount of available glutathion, which can lead to hepatic failure and renal tubular necrosis.

 

Detection Result

Tests Standards Results
Appearance White or almost white ,crystalline powder. White,crystalline powder.
Identification A:IR absorption Complies Complies
B:UV absorption Complies Complies
C:TLC Complies Complies
Melting point 168~172C 169.0~170.9C
Water Not more than0.5% 0.08%
Related substance Impurity(chloroacetanilide)not more than 10 ppm 2ppm
Impurity K(4-aminophenol)not more than 50 ppm 15 ppm
Impurity F(4-nitrophenol)not more than 0.05% Not detected
any other impurity not more than 0.05% 0.01%
Total of other impurities not more than 0.1% 0.02%
Residue on ignition Not more than 0.1% 0.05%
Chloride Not more than 0.014% Less than 0.014%
Sulfate Not more than 0.02% Less than 0.02%
Sulfide Conforms Conforms
Heavy metals Not more than 0.001% Less than 0.001%
Free p-aminophenol Not more than 0.005% Less than 0.005%
Limit of P-chloroacetanilide Not more than 0.001% Less than 0.001%
Readily carbonizable substances Conforms Conforms
Residual solvents Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5% 0.08%
Assay(anhydrous basis) 99.0~101.0% 99.6%
Conclusion: Complies with USP34 / BP2011

 

Paracetamo-Doses

A: Adults including elderly and children over 12 years: 1 or 2 tablets every 4 to 6 hours as required, to a maximum of 8 tablets in a day.

B: Children 6-12 years: Half to 1 tablet every 4-6 hours as required, to a maximum of 4 tablets in a day.

C: Children under 6 years: Not recommended.


Paracetamol-Storage

A: Keep out of the reach and sight of children.
B: Store below 25° C in a dry place, protected from light.
C: Do not use Paracetamol tablets after the expiry date stated on the label/carton/bottle. The expiry date refers to the last day of that month.

 

Paracetamol-Usage

A: Antiinfectant

B: Dispersing agent in liquid scintillation counting

C: Analgesic; antipyretic

D: Antipyretic analgesics, international non proprietary drug called Paracetamol. It is the most commonly used non anti-inflammatory antipyretic analgesic, antipyretic effect similar to aspirin, the analgesic effect is weak, no anti rheumatic effects of anti inflammation, is the best varieties of acetanilide drugs. Particularly suitable for carboxylic acid can not be used drugs patients. For the common cold, toothache embolism. Acetaminophen is intermediate in organic synthesis, photographic chemicals.

E. Used as antipyretic, analgesic, anti rheumatic drugs.

 

Paracetamol 4-Acetamidophenol Superb Analgesic Pharmaceutical Intermediate CAS 103-90-2 0

 

Our advantages


1. High quality with competitive price


1)  Standard:BP/USP/EP/Enterprise standard


2)  All Purity≥99%


3)  We are manufacturer and can provide high quality products with factory price.

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1). Parcel can be sent out in 24 hours after payment.Tracking number available


2). Secure and discreet shipment.Various transportation methods for your choice.


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3. We have clients throughout the world


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