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Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic

Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic

  • Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic
  • Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic
Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic
Product Details:
Place of Origin: China
Brand Name: Pharmlab
Certification: ISO 9001, USP,GMP
Model Number: 34580-14-8
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: negotiation
Packaging Details: Well disguised package ; Plastic drum with safe shipping
Delivery Time: 3~5 work days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: Mass in stock
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Detailed Product Description
Product Name: Ketotifen Fumarate Other Name: Zaditen
Melting Point: 192 °C Storage Temp.: Store At RT
Usage: Vasodilator Chemical Properties: Off-White Solid
High Light:

active pharmaceutical ingredients

,

pharmaceutical grade steroids

Pharmaceutical Raw Materials Ketotifen Fumarate For Antiasthmatic And Antiallergic

 

 

Basic Info.

 

Product Name: Ketotifen fumarate


CAS: 34580-14-8


MF: C23H23NO5S


MW: 425.5


Purity: 98%


EINECS: 252-100-0


Properties: white or pale yellow crystalline powder


Usage: Antiasthmatic; antiallergic.


Catalogue: Pharmaceutical materials drug

 


Description

 

Ketotifen fumarate is a kind of strong anti-allergic drugs containing simultaneously of both tricyclic structure as well as piperidine structure. It is characterized by both a strong antagonism effect on histamine H1 receptor and inhibitory effect of the release of the mediator of allergic reaction. It can inhibit the release various kinds of mediators of mast cells, basophils and macrophages, including the release of slow reacting substances and other active substances. It also has antagonism effect on the calcium ion; can inhibit the activity of phosphodiesterase; increase the intracellular cAMP level inside mast cells. Moreover, it can also inhibiting the chemotaxis and inflammation of neutrophil with an effect 10 times as strong as that of chlorpheniramine, and it also has a long duration time which is better compared with sodium cromolyn. Ketotifen fumarate has therapeutic effect on both Ⅰ and Ⅲ type of allergic reaction. Its peak blood concentrations can sustain for 2 to 3 hours with a half-life of 22 hours during which 60% goes through urinary excretion, 40% goes through the fecal excretion. Children usually have a faster excretion rate of it than adults. Long-term treatment will not cause resistance. No rebound phenomenon will occur with interruption of treatment.

 


Application

 

It has been more than 20 years since ketotifen fumarate have been applied to the prevention and treatment of asthma and childhood asthma. It is a kind of drug with dual effect of both prevention and treatment in the prevention and treatment of asthma and childhood asthma. It should be particularly noted that ketotifen had ever taken as the long-term controlling drug of asthma and childhood long-term asthma and was subject to wide application in many countries. Since the early 1980s, ketotifen fumarate had already been applied in Western Europe, Asia, and China for the prevention and treatment of asthma and asthma in children. But since entering into 21st century, the annual applied amount has decreased year by year. Because of its side effect of inhibition of the central nervous system, its oral tablet currently has still not approved by the FDA and thus failing to enter the US market with only ketotifen fumarate eye drops had been approved by the FDA in 1999. Recent studies have also shown the effectiveness of ketotifen asthma still demands further studies. Moreover, ketotifen fumarate has several additional advantages. First, it can cause sleepiness of the schoolchildren and thus being able to affect their academic performance; second, it can also do harm to the mental development of infants and young children. Thirdly, it is also be able to affect the metabolism of sustained-release tea and thus negatively affecting its anti-inflammatory effects of theophylline. For all the above points, it is not recommended by the GINA (affiliated organization of WHO) to apply ketotifen fumarate for the treatment and prevention of asthma and childhood asthma. But from the perspective of clinical economics, ketotifen fumarate is a suitable anti-allergic drug for being applied in developing countries and rural areas for treating asthma and childhood asthma with certain efficacy due to its relative low price.

 


Chemical Properties

 

This product is white (or light-yellow) crystalline powder, and is odorless with bitter taste. It is slightly soluble in water and ethanol, and easily soluble in methanol but very slightly soluble in chloroform and acetone.

 


Indications

 

Dermatology applies it to the treatment of allergic diseases such as urticaria, pruritus, eczema, atopic dermatitis, and neurodermatitis; it is recently reported that it is also effective in the treatment of scleroderma. For medicine, it has a good efficacy in treating asthma, especially with a significant effect on treating allergic asthma, followed by mixed asthma, and being effective in half of cases for infecting type. It can also be used for the prevention of asthma.

 

Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic 0


Pharmacological effects

 

The pharmacological effect of ketotifen fumarate is very complicated. It has achieved a certain efficacy in the prevention and treatment of asthma and childhood asthma. But the detailed mechanism of its pharmacology remains to be unclear. From the current research information, the pharmacological mechanisms of ketotifen fumarate in treating asthma and childhood asthma include the following several aspects:


1. Antagonizing effect on inflammatory mediators: Clinical studies have already demonstrated that ketotifen fumarate can effectively inhibit the histamine-induced bronchospasm with its intensity being comparable to Azelastine, suggesting that ketotifen fumarate has strong histamine antagonistic effect. Modern studies have shown that ketotifen fumarate may also other inflammatory mediators such as antagonize leukotrienes and platelet activating factor. From this perspective, it is considered that ketotifen is a drug which can antagonize a variety of inflammatory mediators. This may be the primary mechanism for its prevention and treatment of asthma as well as childhood asthma.


2. The membrane protective effect of mast cells/basophils: the related pharmacological studies of ketotifen fumarate have confirmed that it can inhibit mast cell /basophil cells to release inflammatory mediators such as histamine, leukotrienes and platelet activating factor, suggesting that it has a strong membrane protective effects on mast cells/basophils membrane. This may be the major mechanism underlying the dual property of ketotifen fumarate for being able to both prevent and treat the asthma and childhood asthma.


3. The inhibition of airway inflammatory cell infiltration: fumarate ketotifen can inhibit the infiltration of the airways of eosinophil and neutrophil. However, the mechanism remains to be unclear.


4. Regulation of T cell activity: ketotifen fumarate can inhibit the biosynthesis of intracellular lgE through regulating the release activity of CD4 + and CD8 + lymphocytes. The mechanisms of inhibition of the biosynthesis of lgE and the above two mechanisms determines the airway anti-inflammatory effects of ketotifen fumarate.


5. Other effects: Some studies have suggested that ketotifen fumarate can reverse the low-regulation of β2-receptor caused by the long-term administration of β2-receptor agonist and also increase the density of airway β2-receptor as well as enhance the effect of β2-receptor. Some studies have also suggested that ketotifen fumarate also having blocking effect on the calcium channels.

 

Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic 1


Side Effects

 

The most severe side effect of ketotifen fumarate is its inhibitory effect on central nerve system such as causing sleepiness or fatigue, weakness. This side effect is more significant in adults and is one of the major reasons for limiting its clinical application. The resulted sense of lethargy or fatigue, weakness may reduce the life quality of asthma patients as well as children with asthma. Usually, after continuous administration of 1-4 weeks, the side effect of suppression of the central nerve system can significantly reduce and even gradually disappear. Clinical observation has found that combination with theophylline can reduce the central nerve inhibitory effect of ketotifen fumarate as well as offset the stimulus effect on central nerve system of theophylline. But it still demands further observation to demonstrate whether there exist synergistic anti-inflammatory between them. Clinical observations have already confirmed children who administering ketotifen fumarate usually get no significant inhibition of the central nervous system and at most cause only the lower concentration of children’s mind. This is still true even the children subject to an adult dose. However, this mechanism is still unclear. In the clinical observation on the asthma adults patients as well as children patients who subject to 2-year continuous oral administration, wood et al have confirmed that long-term administration of ketotifen fumarate caused no other serious side effects without affecting the liver and kidney function as well as peripheral blood cell counts. It is also not easy to produce drug resistance issues. Usually after continuous oral administration of ketotifen fumarate for six weeks, we can begin to gradually withdraw or reduce the amount of bronchial spasm agent or corticosteroids. Discontinuation of treatment after long-term treatment has not resulted in rebound phenomenon. Therefore, the comprehensive evaluation of the drug is that: ketotifen fumarate is an anti-asthma drug with central nervous inhibition effect (this side effect can gradually adapt), but is relatively safe and effective with certain anti-inflammatory properties and being relatively inexpensive. However, because it has not approved by the FDA, it should be applied with caution in clinical practice.

 

 

Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic 2

 

Products

 

Testosterone Acetate Trenbolone Acetate MGF
Testosterone Cypionate Trenbolone Enanthate PEG MGF
Testosterone Decanoate Boldenone Acetate CJC-1295
Testosterone Enanthate Boldenone undecylenate CJC-1295 DAC
Testosterone Isocaproate Boldenone Cypionate PT-141
TestosteronePhenylpropionate Boldenone Propionate Melanotan-1
Testosterone Propionate Nandrolone Decanoate Melanotan-2
Testosterone Undecanoate Nandrolone phenylpropionate GHRP-2
Mesterone Nandrolone undecylate GHRP-6
Testosterone Sustanon 250 Nandrolone cypionate Ipamorelin
Clostebol Acetate Nandrolone propionate Hexarelin
Methylandrostanolone Methyltrienolone Sermorelin
Methenolone Enanthate Drostanolone Propionate Oxytocin
Methenolone Acetate Drostanolone Enanthate TB500
Anadrol Stanolone Fragment 176-191
Anavar Tadalafil Triptorelin
Winstrol Vardenafil Tesamorelin
Clomifene citrate Dianabol Gonadorelin
Toremifene citrate Tamoxifen Citrate DSIP
Finasteride hydrochloride Selank

 

Peptides Specification:

 

Name Specification Name Specification
MGF 2mg/vial Hexarelin 2mg/vial
PEG MGF 2mg/vial Sermorelin 2mg/vial
CJC-1295 with DAC 2mg/vial Oxytocin 2mg/vial
CJC-1295 without DAC 2mg/vial TB500 2mg/vial
PT-141 10mg/vial BPC 157 2mg/vial
MT-1(Melanotan) 10mg/vial 176-191 2mg/vial
MT-2 10mg/vial Triptorelin 2mg/vial
GHRP-2 5mg/vial Tesamorelin 2mg/vial
GHRP-2 10mg/vial Gonadorelin 2mg/vial
GHRP-6 5mg/vial Gonadorelin 10mg/vial
GHRP-6 10mg/vial DSIP 2mg/vial
Ipamorelin 2mg/vial Selank 5mg/vial

 

Semi Finished Steroids Solution:

 

Testosterone Enanthate(Primoteston) 250mg/ml / 300mg/ml
Testosterone Propionate 100mg/ml
Testosterone Cypionate 250mg/ml / 300mg/ml
Testosterone Sustanon 250 200mg/ml / 250mg/ml
Testosterone Supertest 450 450mg/ml
Nandrolone Decanoate (DECA) 200 / 250 / 300mg/ml
Trenbolone Acetate 100mg/ml
Trenbolone Enanthate(parabola) 200mg/ml
Drostanolone Propionate (Masteron) 100mg/ml
Boldenone Undecylenate (Equipoise) 200mg/ml / 300mg/ml
Methenolone Acetate (Primobolone) 100mg/ml
Anomass 400mg/ml
Ripex 225mg/ml
Tritren 180mg/ml
More More

 

Related Peptides:

 

Peptides List Specification
MGF 2mg
PEG MGF 2mg
CJC-1295 with DAC 2mg
CJC-1295 without DAC 2mg
PT-141 10mg
MT-1(Melanotan-1) 10mg
MT-2(Melanotan-2) 10mg
GHRP-2 5mg
GHRP-2 10mg
GHRP-6 5mg
GHRP-6 10mg
Ipamorelin 2mg
Hexarelin 2mg
Sermorelin 2mg
Oxytocin 1g/2mg
TB500 2mg
pentadecapeptide BPC 157 2mg
Triptorelin 2mg
Tesamorelin 2mg
Gonadorelin 2mg
Gonadorelin 10mg
DSIP 2mg
Selank 5mg
Epitalon 10mg
AOD-9604 2mg
ACE 031 1mg
GDF-8 1mg(-20ºC)
Thyrotropin TRH 1g
Follistatin 315 1mg(-20ºC)
Follistatin 344 1mg(-20ºC)
Deslorelin 20mg
Adipotide 2mg

 

Alarelin Acetate 79561-22-1
Angiotensin Acetate 58-49-1
Argpressin Acetate 113-79-1
Aviptadil Acetate 40077-57-4
Bivalirudin Trifluoroacetate 128270-60-0
Deslorelin Acetate 57773-65-6
Desmopressin Acetate 16679-58-6
Eledoisin Acetate 69-25-0
Eptifibatide Acetate 148031-34-9
Felypressin Acetate 56-59-7
GLP-1 (7-37) Acetate 106612-94-6
Taspoglutide 275371-94-3
Glucagon Hydrochloride 16941-32-5
Lixisenatide 320367-13-3
Gonadorelin Acetate 34973-08-5
Leuprorelin Acetate 53714-56-0
Lysipressin Acetate 50-57-7
Nafarelin Acetate 76932-56-4
Octreotide 79517-01-4
Ornipressin Acetate 3397-23-7
Secretin Acetate 108135-74-8
Somatostatin Acetate 38916-34-6
Splenopentin Acetate 105184-37-0
Terlipressin Acetate 14636-12-5
Teriparatide Acetate 52232-67-4
Triptorelin Acetate 57773-63-4
Vasopressin Acetate 9034-50-8
Bate-Amyloid(1-42)human 107761-42-2
Abarelix Acetate 183552-38-7
Endothelin-1 Acetate 117399-94-7
CRF (human, rat) Acetate 86784-80-7
CRF (ovine) Trifluoroacetate 79804-71-0
Dynorphin A (1-13) Acetate 72957-38-1
Enfuvirtide Acetate (T-20) 159519-65-0
Fertirelin Acetate 38234-21-8
GRF (human) Acetate 83930-13-6
Liraglutide 204656-20-2
Dalmarelin Acetate 61012-19-9
Nesiritide Acetate (BNP-32) 114471-18-0
Pramlintide Acetate 196078-30-5
Salmon Calcitonin Acetate 47931-85-1
tesamorelin 106612-94-6
Tetracosactide Acetate (ACTH 1-24) 16960-16-0
Thymosin α1 Acetate 14636-12-5
Thymosin β4 Acetate 77591-33-4
Atosiban Acetate 90779-69-4
Cetrorelix Acetate 130143-01-0
Exenatide Acetate 141732-76-5
Histrelin Acetate 76712-82-8
Taltirelin Acetate 103300-74-9
Vapreotide Acetate 116430-60-5
Gonaderelin 33515-09-2
Cecropin B 80451-05-4
Oxytocin Acetate 50-56-6
Sincalide 25126-32-3
Protirelin 24305-27-9
Ganirelix acetate 123246-29-7

 

SARMs:

 

Ostarine (MK-2866) CAS: 841205-47-8
Cardarine (GW-501516) CAS: 317318-70-0
Andarine (S4) CAS: 401900-40-1
Ligandrol (LGD-4033) CAS: 1165910-22-4
Ibutamoren (MK-677) CAS: 159752-10-0
RAD140 CAS: 118237-47-0
SR9009 CAS: 1379686-30-2
YK11 CAS: 431579-34-9
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Sex Enhancers:

 

Avanafil CAS: 330784-47-9
Vardenafil CAS: 224785-91-5
CAS: 119356-77-3
Tadalafil CAS: 171596-29-5
Vardenafil Hydrochloride CAS: 431579-34-9
Hydrochloride CAS: 431579-34-9
Yohimbine Hydrochloride CAS: 65-19-0

 

APIs:

 

T3 CAS: 55-06-1
T4 CAS: 51-48-9
Ethyl Oleate(EO) CAS: 111-62-6
Benzyl Alcohol (BA) CAS: 100-51-6
Benzyl Benzoate (BB) CAS: 120-51-4
Grape Seed Oil (GSO) CAS: 85594-37-2
2,4-Dinitrophenol (DNP) CAS: 51-28-5
1,3-Dimethylpentylamine (DMAA) CAS: 13803-74-2
4-Acetamidophenol (Paracetamol) CAS:103-90-2
Tauroursodeoxycholic Acid (TUDCA) CAS: 14605-22-2
Dextromethorphan Hydrobromide (DXM) CAS: 6700-34-1

 

Ketotifen Fumarate Pharmaceutical Anabolic Steroids For Antiasthmatic 3

 

Package

 

We do understand that you will be worried about our packing methods before you tried or knew us, while we are making the real deal and we do know how customs works.

 

We have professional team for special disguised package, no word concern steroid will be whown on the parcels, the pass custom rate is more than 99%.

 

Before we could be able to offer some details of our package and shipping methods, and it is better to discuss by mail , skype or whatsapp.

 

 

Delivery

 

Our company owns a professional and efficient team for packing with our best discrete or stealth packages. Orders will be sent out within only one working day after payment.Package details and tracking number will be sent to you.Shipment by DHL, TNT, FedEx, HKEMS, UPS, ,EUB,ETK and so on.

 

It usually takes 4 to 7 days or 7 to 10 days by some other express courier; it will be 15 to 20 days by slow post.

 

Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.

 

We will stack on the parcels until you get them on hand so that you do not need to spare time on this.

 

 

 

Our commitment:

 

1. Quality assurance

With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

 

2. Safe transportation

Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 3-5 to your product.

 

3. The product diversity

Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter. We absolutely guarantee that you can very safely use our products

 

4. High quality service 

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

Contact Details
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Contact Person: Coco

Tel: +8618186204104

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