|Place of Origin:||China|
|Certification:||ISO 9001, USP,GMP|
|Minimum Order Quantity:||10g|
|Packaging Details:||Well disguised package with safe new shipping method;As requested.|
|Delivery Time:||Shipment within 24 hours, 3 to 5 days arrived|
|Payment Terms:||Western Union, MoneyGram, T/T, bitcoin|
|Supply Ability:||Mass in stock|
|Product Name:||T4||Other Name:||L-Thyroxine Sodium Salt|
|Usage:||Bodybuilding, Burning Fat||Shipping Methods:||EMS,HKEMS,FEDEX,DHL,TNT,Aramex,ETC|
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Healthy Fat Burning Hormones L-Thyroxine T4 Sodium Powder For Fat Loss 51-48-9
Product name: T4
Other name: L-Thyroxine Sodium salt
Molecular Formula: C15H10I4NNaO4
Molecular Weight: 798.85
Appearance: white powder
Grade: Pharmaceutical grade
Certificate: ISO 9001, USP,GMP
Payment: Western Union, MoneyGram, T/T, bitcoin
L-thyroxine is the major hormone derived from the thyroid gland. Thyroxine is synthesized via the
iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in
the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the
blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Levothyroxine is a synthetic levoisomer of thyroxine (T4), similar to the endogenous hormone produced
by the thyroid gland. Thyroxine is de-iodinated to form triiodothyronine (T3) in the peripheral tissues. T3
enters the cell and binds to nuclear thyroid hormone receptors, and the hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration,
thermogenesis, cellular growth and differentiation, and metabolism of proteins, carbohydrates and lipids.
T4 and T3 also possess cardiac stimulatory effect.
L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-
Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in
subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness
Levothyroxine is typically used to treat hypothyroidism, and is the treatment of choice for people with hypothyroidism, who often require lifelong thyroid hormone therapy. It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing. Levothyroxine is also used as interventional therapy in people with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.
A subset of people with hypothyroidism treated with an appropriate dose of levothyroxine will describe continuing symptoms despite TSH levels in the normal range. In these people, further laboratory and clinical evaluation is warranted as they may have another cause for their symptoms. Furthermore, it is important to review their medications and possible dietary supplements as several medications can affect thyroid hormone levels.
Levothyroxine is also used to treat subclinical hypothyroidism which is defined by an elevated TSH level and a normal-range free T4 level without symptoms. Such people may be asymptomatic and whether they should be treated is controversial. One benefit of treating this population with levothyroxine therapy is preventing development of hypothyroidism.
As such, it is recommended that treatment should be taken into account for patients with initial TSH levels > 10 mIU/L, people with elevated thyroid peroxidase antibody titers, people with symptoms of hypothyroidism and TSH levels between 5–10 mIU/L, and women who are pregnant or want to become pregnant. Oral dosing for patients with subclinical hypothyroidism is 1 µg/kg/day.
It is also used to treat myxedema coma, which is a severe form of hypothyroidism characterized by mental status changes and hypothermia. As it is a medical emergency with a high mortality rate, it should be treated in the intensive care unit with thyroid hormone replacement and aggressive management of individual organ system complications.
Dosages vary according to the age groups and the individual condition of the person, body weight and compliance to the medication and diet. Other predictors of the required dosage are sex, BMI, deiodinase activity (SPINA-GD) and etiology of hypothyroidism. Annual or semiannual clinical evaluations and TSH monitoring are appropriate after dosing has been established.
Levothyroxine is taken on an empty stomach approximately half an hour to an hour before meals. As such, thyroid replacement therapy is usually taken 30 minutes prior to eating in the morning. For patients with trouble taking levothyroxine in the morning, bedtime dosing is effective as well. A recent study published in JAMA showed greater efficacy of levothyroxine when taken at bedtime.
L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of
photoperiodic response of gonads in Japanese quail. The product was used as a test compound for
studying the impact of numerous hormones on the surface morphology of rat testicular cells in cultur
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