|Place of Origin:||China|
|Certification:||ISO 9001, USP, GMP|
|Minimum Order Quantity:||negotiation|
|Packaging Details:||Disguised package; Foil bag|
|Delivery Time:||3-5 work days|
|Payment Terms:||Western Union, MoneyGram, T/T, bitcoin|
|Supply Ability:||Mass in stock|
|Product Name:||GDF-8||Specification:||10 Vials/box|
|Purity:||98%min||Appearance:||White Lyophilized Powder|
|Shipping Method:||EMS,HKEMS,FEDEX,DHL,TNT,Aramex,ETC||Shipping Policy:||100% Free Resend Policy|
growth hormone releasing peptide,
human growth hormone powder
|GDF-8 Chemical Name||Growth Differentiation Factor 8|
|GDF-8 Other Names||Myostatin|
|GDF-8 Appearance||White Lyophilized Powder|
|GDF-8 Payment Terms||Western Union, MoneyGram,TT, Bitcoin.|
|GDF-8 Country of Origin||China|
Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength.
The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
|Assay||99.0% min||99. 3%|
|Loss on Drying||6.0%max.||4.80%|
|Acetate Content (HPIC)||12.0%max.||10.80%|
|Peptide Content (N%)||80.0%min.||88.00%|
|Amino Acid Composition||±10% of theoretical||Complies|
|Single Impurity (HPLC)||1.0%max.||0.85%|
A growth factor that regulates the size of muscles beginning in early embryonic development and continuing throughout life. Myostatin acts by inhibiting the growth of muscles, It prevents them from growing too large. Myostatin is also known as growth and differentiation factor 8 (GDF-8)
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|Selank(5mg/bottle)||AOD-9604 221231-10-3(1G / foil bag)|
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