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Clonidine Hydrochloride Clonidine HCL Powder CAS 4205-91-8 for High Blood Pressure Treatment

Clonidine Hydrochloride Clonidine HCL Powder CAS 4205-91-8 for High Blood Pressure Treatment

  • Clonidine Hydrochloride Clonidine HCL Powder CAS 4205-91-8 for High Blood Pressure Treatment
  • Clonidine Hydrochloride Clonidine HCL Powder CAS 4205-91-8 for High Blood Pressure Treatment
Clonidine Hydrochloride Clonidine HCL Powder CAS 4205-91-8 for High Blood Pressure Treatment
Product Details:
Place of Origin: China
Brand Name: Pharmlab
Certification: ISO 9001, USP,GMP
Model Number: 4205-91-8
Payment & Shipping Terms:
Minimum Order Quantity: negotiation
Price: negotiation
Packaging Details: Disguised package ; Foil bag
Delivery Time: 3-5 work days
Payment Terms: Western Union, MoneyGram, T/T, bitcoin
Supply Ability: Mass in stock
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Detailed Product Description
Name: Clonidine Hydrochloride CAS: 4205-91-8
Grade: Pharmaceutical Package: Well Disguised Package ;Foil Bag
Purity: 98% Appearance: White To Off White Crystalline Powder
High Light:

active pharmaceutical ingredients

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pharmaceutical grade steroids

Clonidine Hydrochloride Clonidine HCL Powder CAS 4205-91-8 for High Blood Pressure Treatment

 

What is Clonidine hydrochloride?


Clonidine hydrochloride (trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions. It is classified as a centrally acting α2 adrenergi agonist and imidazoline receptor agonist that has been in clinical use for over 40 years.

 

Basic info.

 

Product name

Clonidine hydrochloride

Synonyms

TIMTEC-BB SBB003065;CLONIDINE HCL;CLONIDINE HYDROCHLORIDE;DIXARIT

CAS NO

4205-91-8

EINECS

224-121-5

MF

C9H10Cl3N3

MW

266.55

Purity

99%

Certification

ISO9001

Brand Name

Pharmlab

Delivery time

4~6 working days once against of the payment

Express delivery

EMS, DHL, TNT, FedEx, UPS

Payment Terms

T/T, Western Union, Money Gram ,Bitcoin

Minimum order

10g

Supply Ability

1000kg/month

Storage

Shading, confined preservation

Packaging

10g/100g/1000g/foil bag According to request.

Appearance

White to off white crystalline powder

Usage

α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.

Categories

Adrenoceptor; Amines; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; CATAPRES; Other APIs


Description of Clonidine


Clonidine is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions. It is classified as a centrally acting α2 adrenergic agonist and imidazoline receptor agonist that has been in clinical use for over 40 years.

 

Application


Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.The Catapres brand of clonidine is used to treat hypertension(high blood pressure). The Kapvay brand is used to treatattention deficit hyperactivity disorder.Clonidine is sometimes given with other medications.

Clonidine is a prescription medication. It's available in these forms: oral immediate-release tablet, patch, and oral extended-release tablet. The form you use may depend on your condition.

 

Clonidine hydrochloride Medical Use

 

Clonidine may be used to ease withdrawal symptoms associated with the long-term use of narcotics, alcohol, benzodiazepine and nicotine (smoking). It can alleviate opioid withdrawal symptoms by reducing the sympathetic nervous system response such as tachycardia and hypertension, as well as reducing sweating, hot and cold flashes, and general restlessness. It may also be helpful in aiding smokers to quit. The sedation effect is also useful. However, its side effects can include insomnia, thus exacerbating an already common feature of opioid withdrawal.

 

Clonidine also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders, and hyperarousal caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders. Clonidine is also a mild sedative, and can be used as premedication before surgery or procedures. Its epidural use for pain during heart attack, postoperative and intractable pain has also been studied extensively. Clonidine has also been suggested as a treatment for rare instances of dexmedetomidine withdrawal. Clonidine can be used in restless legs syndrome. It can also be used to treat facial flushing and redness associated with rosacea. It has also been successfully used topically in a clinical trial as a treatment for diabetic neuropathy. Clonidine can also be used for migraine headaches and hot flashes associated with menopause. Clonidine has also been used to treat diarrhea associated with irritable bowel syndrome, fecal incontinence, diabetes, withdrawal-associated diarrhea, intestinal failure, neuroendocrine tumors and cholera.

 

COA

 


Test Items


Specification


Results


Description


White to off white crystalline powder


Comply


Melting point


166-170°C


167.3-168.1°C


Identification


Positive reaction


Positive reaction


Related substances


≤1.0%


0.16%


Loss on drying


≤0.5%


0.06%


Residue on ignition


≤0.1%


0.02%


Chloride


≤0.014%


<0.014


Heavy Metals


≤20ppm


<20ppm


Clarity of solution


Conform to standard


Complies


Microbial Limit


≤20ppm


<20ppm


Assay


≥99.0%


99.12%

 

Function

 

1 clonidine is α receptor agonists.

2 clonidine directly excited the hypothalamus and delayed brain central synaptic membrane α2 receptor, so that inhibition of neuronal agitation, reduce the central sympathetic nerve impulses, thereby inhibiting peripheral sympathetic nerve activity. Clonidine also excites the peripheral sympathetic synaptic membrane α2 receptor, enhance its negative feedback effect, reduce the release of peripheral nerve release norepinephrine, reduce peripheral blood vessels and renal vascular resistance, slow down the heart rate, lower blood pressure. Renal blood flow and glomerular filtration rate remained essentially unchanged. Symptoms of mild or less common, rarely occurs orthostatic hypotension.

3 clonidine hydrochloride to reduce the median cardiac output (15% to 20%) decreased, without changing the peripheral vascular resistance; 45 ° tilt slightly reduce cardiac output and peripheral vascular resistance. Long-term treatment of cardiac output tends to normal, but the peripheral vascular resistance continued to decline. Most patients with clonidine have heart rate slows down, but the drug has no effect on hemodynamics.

4 clinical studies confirmed that clonidine to reduce plasma renin activity, reduce aldosterone and catecholamines secretion, but these pharmacological effects and the role of antihypertensive relationship is not entirely clear.

5 Acute use of clonidine hydrochloride to stimulate the release of growth hormone in children and adults, but long-term use does not cause growth hormone levels continue to increase.

6 clonidine can treat migraine, dysmenorrhea and menopause hot flashes, but its treatment mechanism is unknown, may play a role in stabilizing the surrounding blood vessels. May be due to inhibition of brain activity of alpha receptors quit addiction. Carcinogenic, mutagenic and reproductive toxicity mice taking 32 to 46 times the maximum recommended dose of clonidine hydrochloride 132 weeks, no carcinogenic events. 3 times the maximum recommended dose of clonidine hydrochloride on the rabbit no teratogenic effect, no erythrocyte toxicity. Clonidine hydrochloride 150mcg / kg or about 3 times the maximum recommended dose of the human body does not affect the reproductive capacity of male or female mice; but 500 ~ 2000mcg / kg or 10 ~ 40 times the maximum recommended dose of the human body, affecting the reproductive capacity of female mice.

 

How to use Clonidine?


The US Food and Drug Administration (FDA) has approved clonidine for that treatment of attention deficit (ADHD), alone or with stimulants this season, for pediatric patients aged 6-17 years.It turned out later approved for adults. Nationwide, clonidine is an accepted and not approved use for ADHD with the TGA. Some research shows clonidine more sedating than guanfacine, which may be better at bedtime along with an arousing stimulant at morning. Clonidine can be utilized in the treatment of Tourette syndrome (particularly for tics). Clonidine may be used to ease withdrawal symptoms from the long-term use of narcotics, alcohol, benzodiazepine and nicotine (smoking).]It can alleviate opioid withdrawal symptoms by lessening the sympathetic neurological system response like tachycardia and hypertension, and reduce sweating, cold and hot flashes, and general restlessness. It may also be helpful in aiding smokers to give up.

 

Clonidine

 

Clonidine Hydrochloride Clonidine HCL Powder CAS 4205-91-8 for High Blood Pressure Treatment 0

 

Clonidine Hydrochloride Clonidine HCL Powder CAS 4205-91-8 for High Blood Pressure Treatment 1

 

Order Process and Tips 

 

Make an order

Please make clear what product and what quantity you need

Mini Order

10g

Quote

Prices and Specifications details(COA) would be offered for you to consider and confirm.

Payment ways

T/T, Western Union, Money Gram and Bitcoin

Delivery ways

All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.)

Shipping address

Provide your Valid and Correct destination address info(if possible with post code, phone number).

Packing

Select best ways according to quantity and safety degree(Super discreet, professional and experienced)

Lead time

Within 12 hours upon receipt of payment

Package pictures

Photos of parcel would be offered to tell apart the items

Tracking number

Offered once it is released

Shipping time

About 5 working days (Door-to-Door)

After-sale service

24/7 Online for any problems

Contact Details
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