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CAS 62568-57-4 Human Peptide Pharmaceutical Delta Sleep Inducing Peptide DSIP

CAS 62568-57-4 Human Peptide Pharmaceutical Delta Sleep Inducing Peptide DSIP

  • CAS 62568-57-4 Human Peptide Pharmaceutical Delta Sleep Inducing Peptide DSIP
  • CAS 62568-57-4 Human Peptide Pharmaceutical Delta Sleep Inducing Peptide DSIP
CAS 62568-57-4 Human Peptide Pharmaceutical Delta Sleep Inducing Peptide DSIP
Product Details:
Place of Origin: China
Brand Name: Pharmlab
Certification: ISO 9001, USP,GMP
Model Number: 62568-57-4
Payment & Shipping Terms:
Minimum Order Quantity: 10grams
Price: negotiable
Packaging Details: Well disguised package ; Plastic drum with safe shipping
Delivery Time: 3~7 work days
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Supply Ability: Mass in stock
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Detailed Product Description
Product Name: DSIP Usage: Anticarcinogenic,Analgesic
Appearance: White Powder Grade: Pharmaceutical Grade
MF: C35H48N10O15 Shiping: EMS,HKEMS,FEDEX,DHL,TNT,Aramex,etc
Package: Well Disguised Package Shipping Policy: 100% Free Resend Shipping
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CAS 62568-57-4 Raw Steroid Powders Pharmaceutical Delta Sleep Inducing Peptide DSIP

 

 

Quick details:

Product Name

DSIP

Sequence

TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU

CAS

62568-57-4

MF

C35H48N10O15

MW

848.81

Purity

99%

Grade

Pharmaceutical Grade

Appearance

White Powder

Specification

2mg/vial

Storage

Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.

 

 

DSIP Description:


Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.


Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities. Its aminoacid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, the gene is unknown[citation needed], raising serious questions regarding the actual existence of this peptide in nature.

 

However, it is the only neuropeptide in history whose gene is unknown, raising serious questions regarding the actual existence of this peptide in nature.

 

CAS 62568-57-4 Human Peptide Pharmaceutical Delta Sleep Inducing Peptide DSIP 0

 

Structure And Interactions

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[5] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids.

Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.

 


DSIP Application:

DSIP is used to help people to fall asleep and keep sleeping. This peptide is welcomed by bodybuilders who understand the function and potential of peptides through training and supplemental programs. In order to help the user sleep better, or can be stacked with other peptides in order to create a comprehensive supplemental procedure, the peptide can be used alone.

 

DSIP reduces basal adrenocorticotropic hormone levels and prevents their release. It also makes the body easier to release LH (luteinizing hormone). In addition, it makes the body easier to release growth hormone (and growth hormone secretion) and prevent the production of somatostatin.

 

This peptide can help people manage stress. In addition, it may have the ability to reduce the symptoms of body temperature. It is also known as an effective means of normal blood pressure and myocardial contraction. Likewise, it can provide the benefits of antioxidants (slowing cell damage).


 

Usage


DSIP (Delta Sleep-inducing Peptide) is a neuropeptide found in the hypothalamus, pituitary, and adrenal glands. Its isolation has allowed for extensive research which has found several possible primary and peripheral roles of this peptide.

 

First, DSIP has been shown to induce sleep. Second, it may have benefits as an analgesic in treatment of chronic pain, sometimes as an adjunct treatment. Third, DSIP has been shown to block ACTH release and decrease levels of ACTH, stimulate LH release, and act as an inhibitor of the secretion of somatostatin.

 

The source of production of DSIP is yet unknown; It may be produced in the central nervous system or in a peripheral organ. It is thought to pass through the blood-brain barrier (BBB) more easily than most known neuropeptides. As mentioned, DSIP has shown positive results in inducing slow-wave EEG (sleep). It has been shown to help treat narcolepsy and restore disturbed sleep patterns to normal sleep rhythms.



DSIP Benefits:

1. Decreases basal corticotropin level and blocks its release.
2. Stimulates release of luteinizing hormone (LH).
3. Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion
4. Can normalize blood pressure and myocardial contraction.
5. It has been found to have anticarcinogenic properties

 

CAS 62568-57-4 Human Peptide Pharmaceutical Delta Sleep Inducing Peptide DSIP 1

 

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