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CAS 2627-69-2 Weight Loss Steroids AICAR Acadesine Pharmaceutical Grade

CAS 2627-69-2 Weight Loss Steroids AICAR Acadesine Pharmaceutical Grade

  • CAS 2627-69-2 Weight Loss Steroids AICAR Acadesine Pharmaceutical Grade
  • CAS 2627-69-2 Weight Loss Steroids AICAR Acadesine Pharmaceutical Grade
CAS 2627-69-2 Weight Loss Steroids AICAR Acadesine Pharmaceutical Grade
Product Details:
Place of Origin: China
Brand Name: Pharmlab
Certification: ISO 9001, USP,GMP
Model Number: 2627-69-2
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: negotiation
Packaging Details: Disguised package ; Foil bag
Delivery Time: 3-5 work days
Payment Terms: Western Union, MoneyGram, T/T, bitcoin
Supply Ability: Mass in stock
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Detailed Product Description
Product Name: AICAR Other Name: Acadesine
CAS: 2627-69-2 Appearance: White Powder
Purity: 99% M.W: 258.23
Formula: C9H14N4O5 Storage: Store At -20°C
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Pharmaceutical SARMs Raw steroids Powder AICAR Acadesine for fat loss

 

Quick detail

 

Product name: AICAR

 

Other name: Acadesine

 

CAS: 2627-69-2

 

Appearance: white powder

 

purity: 99%

 

Trademark: Pharmlab

 

Original: China

 

Grade: Pharmaceutical grade

 

Package: Disguised package ; Foil bag

 

Delivery date: 3-5 work days

 

Certificate: ISO 9001, USP,GMP

 

Payment: Western Union, MoneyGram, T/T, bitcoin

 

Shipping: EMS,HKEMS,EUB,ETK,FEDEX,DHL,UPS,Aramex,ETC

 

Policy: Re-Shipping Policy

 

M.W:258.23

 

Formula:C9H14N4O5

 

Solubility:Soluble to 75 mM in water and to 75 mM in DMSO

 

Storage:Store at -20°C

 

Ysage: AICAR is a nucleoside analog that is capable of entering a nucleotide pool and is capable of significantly increasing adenosine levels during ATP breakdown. Adenosine regulatory agents (ARAs) are considered to have therapeutic potential in myocardial ischemia. Heart protection.

 

 

Aicar COA

 

Item Specification Result
Appearance White powder Complies
Related substance (HPLC) Total impurity ≤0.5%
Max single impurity ≤0.1%
0.2%
0.06%
Odor Characteristic Complies
Assay 99% 99.8%
Sieve analysis 100% pass 80 mesh Complies
Loss on Drying
Residue on Ignition
≤1.0%
≤1.0%
0.12%
0.09%
Heavy Metal <10ppm Complies
As <0.1ppm 0.05ppm
Pb <0.1ppm 0.05ppm
Cd <0.1ppm 0.05ppm
Residual Solvents <100ppm Complies
Residual Pesticide Negative Complies
Microbiology    
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
E.Coli Negative Complies
Salmonella Negative Complies

 

 

Aicar Introduction

 

AICAR is a peptide with the technical name of 5-aminoimidazole-4-carboxamide ribonucleotides. It can also be called AICA ribonucleotides, ZMP or Acadesine. It is an intermediate containing inosine monophosphate. It is primarily an AMP-activated protein kinase agonist, meaning it has the ability to promote nutrient storage for energy production. Molecular weight of 338.211, the formula for the C9H15N4O8P.

 

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain the steady state of cell energy (Hardie and Carling).

 

AICAR can play a role in promoting these processes because it contains the ability to penetrate the heart cells and prevent the production of enzymes associated with regulation of glucose intake and energy excretion. Inhibition of these regulatory enzymes, the affected cells, in turn, can increase the amount of acceptable glucose and also increase their energy conversion levels. In addition, the presence of peptides has been identified to help reduce programmed cell death, which is also known as apoptosis.

 

 

AICAR Application

lose weight

 

AICAR is a peptide, it is a generation of inosinic acid in an intermediate, and metabolic regulation is directly related. The most important mechanism known to AICAR is its ability to block enzymes at both intracellular and extracellular levels, which in turn allows accelerated stimulation of glucose uptake and increased protein kinase in skeletal muscle tissue. These two functions allow more energy conversion, which helps to burn fat and maintain the output of the activity. Scientists and athletes / bodybuilders are interested in this.

 

AMP activates protein kinase

 

The main mechanism of AICAR is to activate AMPK (AMP-activated protein kinase). Thus, activating AMPK can make the same cellular mechanism (which can be said to be opened) as if cells were consumed by energy, such as strong exercise, or from low calorie intake.

 

A sufficient and considerable concentration of AICAR is effective in activating AMPK and inducing cell status as if it had been exercised or had low energy storage and therefore needed to burn fat.

 

AICAR uses metabolic pathways to block certain enzymes, which allow AMP to activate the protein kinase. This can be explained by the layman: Once you have taken a lot of AICAR, it deceives your body at the cellular level and thinks that this exercise has just finished. Since the body thinks that a considerable amount of exercise has just been carried out, the cellular energy cycle begins to transform the fuel source, such as fatty acids, to output the energy that is considered to be spent in motion. This can directly affect the level of endurance activity and the sustainability of the activity. Insulin sensitivity is also considered to be a behavior of AICAR, because the body will think that it is only experienced a series of exercises. Interestingly, in animal studies of obese mice, AICAR showed the benefits of all peptides in obese diet-induced mice while healthy lean mice did not gain any benefit of increased insulin sensitivity or increased glucose uptake. Having said that, fitness applications do not seem appropriate, because these mechanisms are for shape and overweight.

 

Prevent ischemic injury

 

Interestingly, AICAR has been shown to prevent ischemic injury. This type of damage is directly related to the limits of blood on the tissue, which may lead to the lack of oxygen and glucose required to keep tissue alive. This can lead to thrombosis, embolism and vasoconstriction. AICAR can be used as a stable peptide for ischemic attack and can allow appropriate blood flow to the heart (heart). This feature is very interesting because AICAR can be used fundamentally to treat heart attacks for heart muscles. This may reduce the likelihood of ischemic injury. In animal studies using peptide AICAR, abnormal growth in cardiac tissue and heart valve function has also changed, which is disadvantageous.

 

 

Product Features

 

AICAR (AICA-Riboside) strongly inhibits transcription of PPARα and co-activation of PPARα. It has been shown in adipocyte studies that antagonizing lipolysis induced by isoproterenol and has been suggested for kinase cascade studies. In addition, studies have shown that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies have shown that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase) and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is a monophosphorylated derivative of AICA-riboside which can be used as an aminoimidazole carboxamide ribonucleotide invertase / inosine monophosphate cyclase hydrolase ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 kinases.

 

 

AMP activates protein kinase (AMPK) as a metabolic sensor that regulates lipid and glucose metabolism, maintains cell homeostasis and protects against metabolic stress, a selective activator of AMPK in hepatocytes and adipocytes. At 0.5 mM, it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of the control and is in the 3T3-L1 Fat cells reduced by 2.5 times the GLUT4 translocation. It also blocked the expression of proinflammatory cytokines (TNF-α / IL-1β and IL-6), iNOS, COX-2 and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C / EBP pathways.

 

 

Biological activity

 

AICAR is a cell osmotic activator of AMP-activated protein kinase (AMPK), a metabolic major regulator that is activated when energy availability is reduced (high-cell AMP: ATP ratio) and is used to inhibit the metabolic process. In vivo, AMPK and AICAR pharmacological activation simulates exercise and triggers skeletal muscle independent of insulin glucose uptake.

 

AMP - activated protein kinase (AMPK) cells are permeable to allosteric activators. Enhance the proliferation, differentiation and mineralization of osteoblast MC3T3-EI cells and attenuate the expression of proinflammatory cytokines and iNOS in astrocytes induced by psychosis. Promote osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

 

 

AICAR / ACADESINE Usage

 

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain the steady state of cell energy (Hardie and Carling).

 

AICAR can play a role in promoting these processes because it contains the ability to penetrate the heart cells and prevent the production of enzymes associated with regulation of glucose intake and energy excretion. Inhibition of these regulatory enzymes, the affected cells, in turn, can increase the amount of acceptable glucose and also increase their energy conversion levels. In addition, the presence of peptides has been identified to help reduce programmed cell death, which is also known as apoptosis.

 

 

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WHY CHOOSE US?
For quality 1.Our company is a professional raw powder factory in China
for over 10 years, all powders are factory directly supplying.
2.we have a standardized laboratory, all of our products
have to be tested in professional lab before selling,
it must meet the in-house quality control standard.
For delivery 1.we have been in this field for many years,
we have accumulated a lot of experience.
2.Different countries have different package
and shipping methods.
For Price 1.as a experienced supplier, we won't offer you crazy price,
because it's not in line with the market trend.
The most favorable factory price will be provided, so please rest assured to order from us.


 

 

how to make order
step1 Pre-sale service 1.As for your every inquiries, we always reply timely and patiently.
All of the relevant information will be provided to
help you to make a wise choice
2. if you need we can offer provide you with COA ,
Cook Recipes Of Steroid Oil , Feedback Of Other Customers
Step2 payment 1.we'd like to accept bank transfer, Western Union , Moneygram , Bitcoin
Step3 delivery 2.we are support Transportation: DHL, UPS, TNT, EMS,
Hongkong EMS, FedEx or Other
3.After confirming your payment, shipping arrangement
and package pictures will be provided within 24 Hours ;
Tracking number will be provided within 72 Hours.
4.For important parcel information, such as:
Left Original Country , Arrived At Destination Country ,
Passed Customs , Out For Delivery , Delivered,
those information will be sent to you timely.
Step4 After-sales
service
1.you could consult us for any questions,
we offer 7*24h good servies and Tech-support.

 

 

Our Service
Fast Delivery Delivery within 24 hours upon receipt of your payment
Quality Quality can be promised. Hot sell to Worldwide
Payment Terms T/T Bank Transfer, Western Union, Paypal, Bitcoin and MoneyGram Available
Sample Sample available at any time
Tracking your order at any time Inform your order's further new situation at any time
Package Professional packing with professional materials

 

 

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