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White Male Enhancement Steroids Hydrochloride For Premature Ejaculation

White Male Enhancement Steroids Hydrochloride For Premature Ejaculation

    • White Male Enhancement Steroids  Hydrochloride For Premature Ejaculation
    • White Male Enhancement Steroids  Hydrochloride For Premature Ejaculation
  • White Male Enhancement Steroids  Hydrochloride For Premature Ejaculation

    Product Details:

    Place of Origin: China
    Brand Name: Pharmlab
    Certification: ISO 9001 ,USP,GMP
    Model Number: 119356-77-3

    Payment & Shipping Terms:

    Minimum Order Quantity: 10grams
    Price: negotiation
    Packaging Details: Disguised pacakge ; Foil bag
    Delivery Time: 3-5 work days
    Payment Terms: T/T, Western Union, MoneyGram, Bitcoin
    Supply Ability: Mass in stock
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    Detailed Product Description
    Product Name: Hydrochloride Other Name: HCL
    CAS: 119356-77-3 Appearance: White Crystal Powder
    Grade: Pharmaceutical Grade Purity: 99.61% By HPLC On Dry Basis
    MF: C21H23NO.ClH MW: 341.88
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    Male Sex Enhancement HCL Hydrochloride For Premature Ejaculation

     


    Basic Info.

     

    Product Name: Hydrochloride

     

    CAS: 119356-77-3

     

    MF: C21H23NO.ClH

     

    MW: 341.88

     

    Purity: 99.61% by HPLC on dry basis

     

    Appearance: White crystalline powder

     

    Storage: Shading, confined preservation

     

    Standard: USP, BP, EP, Enterprise standard

     

    Categories: Erectile Dysfunction;API; hydrochloride

     

    Usage: A selective serotonin reuptake inhibitor (SSRI); hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men.

     


    Product Detail

     

    Product Name HCL
    Chemical Name Hydrochloride
    CAS Number 129938-20-1
    Molecular Formula C21H24ClNO
    Molecular Weight 341.8744
    Appearance White crystalline powder
    Melting Point 175-179C
    Purity 99.5%
    Usage A Selective Serotonin Reuptake Inhibitor (SSRI)

     


    Introduction

     

    Premature ejaculation (PE) is the most common male sexual dysfunction. hydrochloride,marketed as and Westoxetin, is a class of PE treatment drugs known as selective serotonin reuptake inhibitors (SSRI) , was the first drug originally approved for the on-demand treatment of men 18-64 years old with PE.

     

    works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a result promoting ejaculatory delay. was initially developed as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

     

    Used for the treatment of premature ejaculation and erectile dysfunction. Over 98% of men taking this drug will naturally gain a improved erection quality with prolonged time and more frequencies.

    Physical and chemical properties


    White crystal powder with sweet taste and no odor, hygroscopic and soluble in water. It has a stable chemical property with the melting point at 175~177℃.

     


    PE treatment

     

    Premature ejaculation (PE) is a common problem worldwide and has significant impact not only on the sufferer but on the partner in terms of self-esteem, interpersonal distress and sexual satisfaction. Tricyclic antidepressants and clomipramine are the most widely used drugs for the treatment of premature ejaculation .

     

    Randomized, double blind, placebo-controlled trials have confirmed the efficacy of for the treatment of PE. Different dosage has different impacts on different type of PE. 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. , giving 1-3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used.

     

    However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug's accumulation in the body, and therefore reducing side effects.

     


    Mechanism of Actions

     

    The mechanism through which affects premature ejaculation is still unclear. However, it is presumed that works by inhibiting serotonin transporter and subsequently increasing serotonin's action at pre and postsynaptic receptors. Human ejaculation is regulated by various areas in the central nervous system (CNS). The ejaculatory pathway originates from spinal reflex at the thoracolumbar and lumbosacral level of spinal cord activated by stimuli from male genital. These signals are relayed to the brain stem, which then is influenced by a number of nuclei in the brain such as medial preoptic and paraventricular nulcei. Clement's study performed on anaesthetized male rats showed that acute administration of inhibits ejaculatory expulsion reflex at supraspinal level by modulating activity of lateral paragigantocellular nucleus (LPGi) neurons. These effects cause an increase in pudendal motoneuron reflex discharge (PMRD) latency. However, it is unclear whether acts directly on LPGi or on the descending pathway in which LPGi located.

     


    Development in Marketing internationally

     

    Originally developed by Eli Lilly pharmaceutical company, was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. is sold in some European and Asian countries, and in Mexico. In the US, has been in phase III development since 2003. However, it was rejected by FDA last year. In 2012, Menarini acquired the rights to sell in Europe, most of Asia, Africa, Latin America and the Middle East.

     


    Usage and Dosage

     

    Oral administration of one pill 20-30 mins before sexual intercourse; it can be taken irregularly; it’s better to take it with an empty stomach; avoid fatty food during administration; no tea before administration. Its effect is significant when the user under sexual stimulus.

     


    Contraindications

     

    A contraindication is a situation in which a drug should not be used, because it may be harmful to the patient. Juveniles, children and pregnant women are not allowed to take . should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole, ritonavir, and telithromycine. can also not be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart disease. Caution is advised in men receiving thioridazine, monoamine oxidase inhibitors, SSRIs, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressant. If a patient stops taking one of these drugs, he should wait for 14 days before taking . If a patient stops taking , he should wait for 7 days before receiving these drugs.

     

     

    Spefication:

     

    Items of analysis Specification Results
    Characteristics White or almost white crystalline powder White crystalline powder
    Melting point 175.0~177.0ºC 176.0ºC
    Specific rotatlon +128°±3(C=1,CH3OH) +128°±3(C=1,CH3OH)
    Loss on drying ≤0.5% 0.32%
    Heavy metals 0ppm 0ppm
    Relative substance Total impurity≤0.1% 0.07%
    Assay(on dried basis) ≥99.5% 99.61%
    Conclusion It complies to enterprise standard

     

     

    White Male Enhancement Steroids  Hydrochloride For Premature Ejaculation 0

     

     

    Packaging & Delivery

     

    1. Professional team for package and shipment.Special way to ship 100grams to 100kg powders at one time to your country.

     

    2. Fast and discreet shipment could be arranged for customs pass Guaranteed.

     

    3. Tracking code 24 hours for customs pass guaranteed.

     

    4. Many kinds of shipment, also can be as your requirement.

     


    Our Advantage

     

    1. Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.

     

    2. We have a more profound professional knowledge, you can do a full range of services.

     

    3. Great quality,favorable price and safe transport.

     

    4. Secure and discreet shipment.

     

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