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Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2

Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2

    • Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2
    • Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2
  • Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2

    Product Details:

    Place of Origin: China
    Brand Name: Pharmlab
    Certification: ISO 9001, USP,GMP
    Model Number: CAS: 23964-57-0

    Payment & Shipping Terms:

    Minimum Order Quantity: 1kg
    Price: negotiation
    Packaging Details: Foil bag ; 25kg/drum ; Disguised package
    Delivery Time: 3~5 work days
    Payment Terms: T/T, Western Union, MoneyGram
    Supply Ability: Mass in stock
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    Detailed Product Description
    Product Name: Articaine Hydrochloride Other Name: Articaine HCl
    CAS No-8: 23964-57-0 Appearance: White Or Off White Crystalline Powder
    Catagory: Local Anesthetics Usage: Anti Paining
    MF: C18H29ClN2O MW: 324.89

    Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2​

     

    What is Levobupivacaine Hydrochloride?

     

    Levobupivacaine Hydrochloride is the hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property.


    Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.


    Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AbbVie under the trade name Chirocaine.

     

     

    Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2

     

    Quick Details

     

     

    Product Name Levobupivacaine hydrochloride
    CAS 27262-48-2
    MF C18H29ClN2O
    MW 324.89
    Purity 99%
    Appearance white crystalline powder
    Usage Local anaesthetics
    Categories Pharmaceutical Raw Materials;Active Pharmaceutical Ingredients;API;Inhibitors
    Synonyms TIMTEC-BB SBB001337;(S)-(-)-BUPIVACAINE HCL;
    (S)-(-)-BUPIVACAINE HYDROCHLORIDE;
    (S)-(-)-1-N-BUTYL-2',6'-DIMETHYL-2-PIPERIDINCARBOXANILID HYDROCHLORIDE; (S)-(-)-1-BUTYL-2-(2,6-XYLYLCARBAMOYL)-PIPERIDINE HYDROCHLORIDE; s-(-)-1-butyl-2',6'-pipecoloxylidide hydrochloride; (s)-1-butyl-2',6'-piperidinecarboxamidemonohydrochloride; (s)-1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamidemonohydrochloride

     

    Description

     

    Levobupivacaine (rINN) is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine.

     

    The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.

     
     
    Application
     
     

    Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine. Bupivacaine is an amide-type local anaesthetic. Although it blocks neuro transmission, its membrane stabilising action also affects the myocardium. This can cause fatal cardiotoxicity. As bupivacaine is widely used in surgery and obstetrics, attempts have been made to develop a safer long-acting local anaesthetic.

    The bupivacaine molecule is a racemic compound. Levobupivacaine is the S-enantiomer of bupivacaine and is thought to have less cardiotoxic potential than the R-enantiomer. The pharmacokinetic parameters of levobupivacaine are similar to those of bupivacaine.

    Levobupivacaine has been studied in surgical anaesthesia and for pain management. It can be used for local infiltration, epidural, intrathecal and peripheral nerve blocks. For epidural analgesia it can be given with clonidine. Double-blind comparisons of levobupivacaine and bupivacaine show that their anaesthetic effects are similar.

     

     

    Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2

     

    Dosage and Usage


    Indications are mainly used for surgical epidural anesthesia.Adult for nerve block or infiltration anesthesia, a maximum dose of 150mg. Concentration of the preparation of the solution: surgical epidural block: 0.5% ~ 0.75% 10 ~ 20ml 50 ~ 150mg moderate to all motor block.

     

    COA

     
    Product Name Levobupivacaine hydrochloride  
    Batch . 15061201 Mfg. date 2016.06.12
    Approval Date 2016.06.23 Exp. date 2018.06.01
    Description White Or Almost White Crystalline Powder Date of Expiry 2017.12.01
    Results Of Analysis Tests
    Test Analysis Standard Results
    Melting Point 139~145ºC 139.5~142.5ºC
    Specific Rotation +55°~ +58° +57.2°
    Loss On Drying 0.32% ≤1.0%
    Residue On Ignition 0.03% ≤0.2%
    Assay 99.36% 98.0%~101.0%
    Conclusion Be Conform With Enterprise Standard
    Molecular formula
    Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2

     

     

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    Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2

    Levobupivacaine Pain Relief Powder Local Anesthetic Drugs Levobupivacaine Hydrochloride CAS 27262-48-2

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